HitPredict

Interactor 1: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Interactor 2: RD23A (P54725)
UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)
Gene: RAD23A

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	19013454
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 363
+	Rn
		1117333 PRS6B_RAT (1-418): 2.5e-139: 406: 99.76		RD23B_RAT (3-363): 6.38e-109: 326: 52.05
+	Hs
		798621 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		RD23B_HUMAN (3-363): 1.37e-106: 320: 54.03
+	Rn
		1104198 Q32PW9_RAT (41-417): 2.28e-125: 369: 41.11		RD23B_RAT (3-363): 6.38e-109: 326: 52.05
+	Hs
		872250 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		RD23B_HUMAN (3-363): 1.37e-106: 320: 54.03
+	Dm
		1359291 Q9V405_DROME (4-418): 6.87e-131: 384: 86.27		Q9V3W9_DROME (3-362): 9.91e-87: 269: 38.43
+	Sc
		697066 PRS6B_YEAST (1-418): 7.52e-127: 374: 66.82		RAD23_YEAST (3-361): 1e-75: 240: 28.57
+	Sc
		697092 PRS4_YEAST (34-414): 2.92e-124: 368: 50.38		RAD23_YEAST (3-361): 1e-75: 240: 28.57
+	Hs
		798782 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47
+	Hs
		798776 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08
+	Mm
		872749 PRS6B_MOUSE (1-418): 2.5e-139: 406: 99.76		UBQL2_MOUSE (2-312): 1.71e-45: 166: 14.79
+	At
		1352317 PRS4A_ARATH (8-412): 1.44e-135: 397: 47.43		DSK2A_ARATH (1-318): 3.51e-44: 161: 15.17
+	Hs
		798608 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		BAG6_HUMAN (2-307): 5.25e-38: 146: 15.22
+	Hs
		913367 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		UBQL1_HUMAN (2-312): 9.5e-48: 171: 14.47
+	Hs
		913364 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		UBQL2_HUMAN (2-312): 1.85e-45: 166: 16.08
+	Hs
		913358 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		UBQL4_HUMAN (3-312): 3.05e-45: 165: 15.57
+	Xl
		804064 PRS8_XENLA (38-418): 8.88e-125: 370: 42.00		BAG6A_XENLA (3-307): 4.47e-39: 149: 15.74
+	Hs
		474950 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		UBB_HUMAN (3-81): 4.96e-28: 111: 30.38
+	Sc
		703820 PRS6B_YEAST (1-418): 7.52e-127: 374: 66.82		DSK2_YEAST (1-246): 3.36e-35: 134: 20.65
+	Hs
		913240 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		RL40_HUMAN (3-129): 1.37e-38: 136: 22.84
+	Hs
		913239 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		RS27A_HUMAN (3-93): 2.9e-16: 77.1: 27.47