HitPredict

Interactor 1: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Interactor 2: RD23B (P54727)
UV excision repair protein RAD23 homolog B (HR23B) (hHR23B) (XP-C repair-complementing complex 58 kDa protein) (p58)
Gene: RAD23B

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35271311, 27114451
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 409
+	Rn
		1117333 PRS6B_RAT (1-418): 2.5e-139: 406: 99.76		RD23B_RAT (1-409): 1.14e-120: 358: 87.23
+	Hs
		872250 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		RD23B_HUMAN (1-409): 1.31e-125: 370: 100.00
+	Hs
		798620 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		RD23A_HUMAN (1-409): 9.12e-94: 287: 56.72
+	Dm
		1359291 Q9V405_DROME (4-418): 6.87e-131: 384: 86.27		Q9V3W9_DROME (1-408): 5.38e-89: 277: 36.75
+	Sc
		697066 PRS6B_YEAST (1-418): 7.52e-127: 374: 66.82		RAD23_YEAST (1-407): 2.12e-72: 233: 28.41
+	Hs
		798782 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		UBQL1_HUMAN (1-404): 1.25e-57: 200: 13.72
+	At
		1352317 PRS4A_ARATH (8-412): 1.44e-135: 397: 47.43		DSK2A_ARATH (1-407): 2.58e-59: 203: 17.08
+	Hs
		798776 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		UBQL2_HUMAN (1-364): 5.93e-51: 182: 13.68
+	Mm
		872749 PRS6B_MOUSE (1-418): 2.5e-139: 406: 99.76		UBQL2_MOUSE (1-364): 6.58e-49: 177: 13.26
+	Dm
		1359420 Q9V405_DROME (4-418): 6.87e-131: 384: 86.27		Q9VWD9_DROME (1-353): 1.07e-44: 164: 11.08
+	Mm
		476722 PRS6B_MOUSE (1-418): 2.5e-139: 406: 99.76		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Hs
		913358 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		UBQL4_HUMAN (1-364): 2.75e-45: 166: 12.71
+	Hs
		474950 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		UBB_HUMAN (1-79): 1.99e-32: 123: 30.38
+	At
		1092354 PRS4B_ARATH (8-412): 2.16e-135: 397: 47.19		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75
+	At
		1092413 PRS4A_ARATH (8-412): 1.44e-135: 397: 47.43		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75
+	Mm
		476747 PRS10_MOUSE (35-417): 3.49e-126: 371: 40.47		UBC_MOUSE (1-118): 1.78e-32: 131: 21.67
+	Hs
		913240 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		RL40_HUMAN (1-91): 3.57e-33: 122: 28.57
+	At
		1092257 PS10B_ARATH (33-414): 3.74e-126: 372: 40.72		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75
+	At
		1092308 PRS6B_ARATH (17-418): 2.02e-126: 372: 79.60		UBQ3_ARATH (1-80): 7.66e-29: 116: 28.75
+	Hs
		913239 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		RS27A_HUMAN (1-90): 2.4e-15: 75: 26.67