HitPredict

Interactor 1: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Interactor 2: SEM1 (P60896)
26S proteasome complex subunit SEM1 (26S proteasome complex subunit DSS1) (Deleted in split hand/split foot protein 1) (Split hand/foot deleted protein 1) (Split hand/foot malformation type 1 protein)
Gene: SEM1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.54	0.60	0.571

Property	Details
Experiments	15610744, 35271311
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	3

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 70
+	Hs
		893531 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00
+	Hs
		893530 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00
+	Hs
		893529 PRS4_HUMAN (32-412): 2.96e-120: 358: 49.09		SEM1_HUMAN (1-70): 3.65e-23: 84.7: 100.00