HitPredict

Interactor 1: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Interactor 2: PAAF1 (Q9BRP4)
Proteasomal ATPase-associated factor 1 (Protein G-16) (WD repeat-containing protein 71)
Gene: PAAF1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.86	0.60	0.720

Property	Details
Experiments	17353931, 28514442, 33961781, 35271311, 15831487
Identification Methods	affinity chromatography technology, anti bait coimmunoprecipitation, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000502 - proteasome complex
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 392
+	Hs
		792936 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		LIS1_HUMAN (130-391): 7.01e-70: 227: 18.06
+	Hs
		913344 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		907142 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		906912 PRS4_HUMAN (32-412): 2.96e-120: 358: 49.09		PAAF1_HUMAN (1-392): 2.05e-83: 261: 98.47
+	Hs
		913238 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		GBB2_HUMAN (64-350): 1.04e-69: 224: 22.56
+	Hs
		792951 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		LIS1_HUMAN (130-391): 7.01e-70: 227: 18.06
+	Hs
		906981 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		GBB2_HUMAN (64-350): 1.04e-69: 224: 22.56
+	Sc
		744630 PRS4_YEAST (34-414): 2.92e-124: 368: 50.38		TAF5_YEAST (126-391): 8.85e-57: 200: 17.59
+	Hs
		907118 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		FBXW7_HUMAN (167-390): 5.39e-51: 183: 14.98
+	Sc
		703828 PRS6B_YEAST (1-418): 7.52e-127: 374: 66.82		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Hs
		798631 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Sc
		771723 PRS4_YEAST (34-414): 2.92e-124: 368: 50.38		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Sc
		860034 PRS10_YEAST (12-418): 2.63e-120: 358: 40.34		RPN14_YEAST (111-340): 7.56e-26: 109: 30.49
+	Hs
		903094 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Hs
		903081 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		WDR5_HUMAN (314-390): 8.57e-15: 76.6: 9.88
+	Mm
		907215 PRS8_MOUSE (38-418): 1.7e-122: 362: 42.26		PRP19_MOUSE (89-204): 4.15e-13: 72.4: 33.06