HitPredict

Interactor 1: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Interactor 2: AMRA1 (Q9C0C7)
Activating molecule in BECN1-regulated autophagy protein 1 (DDB1- and CUL4-associated factor 3)
Gene: AMBRA1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	25499913
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 418 Hs			1 1298
+	Hs
		913348 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		907151 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		906916 PRS4_HUMAN (32-412): 2.96e-120: 358: 49.09		AMRA1_HUMAN (1-1298): 0: 1603: 100.00
+	Hs
		798631 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		903094 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		903081 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		WDR5_HUMAN (3-297): 2.47e-87: 289: 18.39
+	Hs
		792936 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		LIS1_HUMAN (123-346): 3.66e-35: 141: 11.45
+	Sc
		744630 PRS4_YEAST (34-414): 2.92e-124: 368: 50.38		TAF5_YEAST (9-127): 1.2e-32: 139: 22.22
+	Hs
		792951 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		LIS1_HUMAN (123-346): 3.66e-35: 141: 11.45
+	Hs
		907118 PRS8_HUMAN (38-418): 1.7e-122: 362: 42.26		FBXW7_HUMAN (164-329): 5.74e-18: 91.8: 9.58