HitPredict

Interactor 1: PRS6B (P43686)
26S proteasome regulatory subunit 6B (26S proteasome AAA-ATPase subunit RPT3) (MB67-interacting protein) (MIP224) (Proteasome 26S subunit ATPase 4) (Tat-binding protein 7) (TBP-7)
Gene: PSMC4

Interactor 2: UBQL1 (Q9UMX0)
Ubiquilin-1 (Protein linking IAP with cytoskeleton 1) (PLIC-1) (hPLIC-1)
Gene: UBQLN1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35271311, 27114451
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	AAA~ubiquitin
Common GO terms	GO:0000502 - proteasome complex GO:0005654 - nucleoplasm GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 418 Hs			1 589
+	Hs
		913367 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		UBQL1_HUMAN (1-589): 1.23e-174: 509: 100.00
+	Hs
		798776 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Mm
		872749 PRS6B_MOUSE (1-418): 2.5e-139: 406: 99.76		UBQL2_MOUSE (1-589): 8.33e-141: 424: 65.47
+	Hs
		913364 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		UBQL2_HUMAN (1-589): 9.51e-145: 433: 71.29
+	Dm
		1359420 Q9V405_DROME (4-418): 6.87e-131: 384: 86.27		Q9VWD9_DROME (30-582): 3.32e-135: 407: 47.39
+	Hs
		913358 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		UBQL4_HUMAN (28-589): 1.35e-135: 409: 57.64
+	Dm
		186163 PRS8_DROME (38-418): 1.01e-125: 371: 41.73		Q9VWD9_DROME (30-582): 3.32e-135: 407: 47.39
+	At
		1352317 PRS4A_ARATH (8-412): 1.44e-135: 397: 47.43		DSK2A_ARATH (19-586): 8.36e-108: 336: 32.87
+	Xl
		804064 PRS8_XENLA (38-418): 8.88e-125: 370: 42.00		BAG6A_XENLA (31-536): 8.79e-64: 229: 15.26
+	Hs
		798721 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		DDI1_HUMAN (47-318): 6.39e-53: 187: 15.60
+	Hs
		798691 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Hs
		913323 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		DDI1_HUMAN (47-318): 6.39e-53: 187: 15.60
+	Dm
		186166 PRS8_DROME (38-418): 1.01e-125: 371: 41.73		Q9VXF9_DROME (37-317): 4.08e-51: 184: 17.93
+	Hs
		913291 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		DDI2_HUMAN (47-318): 2.03e-49: 178: 13.52
+	Hs
		798608 PRS6B_HUMAN (1-418): 3.22e-139: 406: 100.00		BAG6_HUMAN (25-536): 2.14e-33: 138: 14.66
+	Dm
		1359291 Q9V405_DROME (4-418): 6.87e-131: 384: 86.27		Q9V3W9_DROME (37-394): 1.42e-40: 154: 13.95
+	Sc
		697066 PRS6B_YEAST (1-418): 7.52e-127: 374: 66.82		RAD23_YEAST (45-419): 1.17e-31: 128: 17.73
+	Sc
		703820 PRS6B_YEAST (1-418): 7.52e-127: 374: 66.82		DSK2_YEAST (36-243): 8.16e-32: 128: 30.73
+	Hs
		913240 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		RL40_HUMAN (37-126): 1.88e-34: 128: 30.77
+	Hs
		913239 PRS10_HUMAN (35-417): 3.49e-126: 371: 40.47		RS27A_HUMAN (37-123): 1.1e-12: 68: 30.68