HitPredict

Interactor 1: CSN1 (P45432)
COP9 signalosome complex subunit 1 (CSN complex subunit 1) (Constitutive photomorphogenesis protein 11) (Protein FUSCA 6)
Gene: CSN1

Interactor 2: CSN3 (Q8W575)
COP9 signalosome complex subunit 3 (Signalosome subunit 3) (Protein FUSCA 11)
Gene: CSN3

Species: Arabidopsis thaliana

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	22133685, 11684663, 12615944, 15703063
Identification Methods	affinity chromatography technology, two hybrid, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	PCI~PCI, PCI~RPN7
Common GO terms	GO:0000338 - protein deneddylation GO:0005737 - cytoplasm GO:0008180 - COP9 signalosome GO:0009585 - red, far-red light phototransduction
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 441 At			1 429
+	At
		799481 CSN1_ARATH (1-441): 7.1e-135: 396: 100.00		PSD11_ARATH (8-385): 8.2e-90: 280: 12.66
+	Mm
		102341 G3UXW9_MOUSE (28-440): 4.8e-105: 323: 45.64		CSN3_MOUSE (6-428): 1.09e-116: 349: 37.76
+	Mm
		291850 CSN1_MOUSE (28-440): 5.96e-104: 318: 45.64		CSN3_MOUSE (6-428): 1.09e-116: 349: 37.76
+	Hs
		1024241 CSN1_HUMAN (28-440): 1.81e-100: 310: 45.00		CSN3_HUMAN (6-428): 3.09e-116: 347: 37.76
+	Hs
		198630 PSMD6_HUMAN (32-428): 2.95e-109: 329: 19.35		PSMD3_HUMAN (47-424): 2.86e-96: 300: 20.51
+	Dm
		627131 PSMD6_DROME (31-428): 1.38e-101: 309: 17.54		PSMD3_DROME (8-420): 9.69e-100: 308: 19.72
+	At
		799473 CSN1_ARATH (1-441): 7.1e-135: 396: 100.00		CSN2_ARATH (30-381): 1.92e-64: 215: 9.92
+	Hs
		121764 PSMD6_HUMAN (32-428): 2.95e-109: 329: 19.35		PSD11_HUMAN (55-393): 6.12e-81: 257: 13.19
+	Dm
		1180710 PSMD6_DROME (31-428): 1.38e-101: 309: 17.54		PSD11_DROME (55-394): 6.36e-79: 252: 13.16
+	Mm
		102346 G3UXW9_MOUSE (28-440): 4.8e-105: 323: 45.64		CSN2_MOUSE (33-384): 4.6e-73: 237: 11.17
+	Ce
		981854 PSMD6_CAEEL (23-427): 6.13e-103: 314: 20.82		PSMD3_CAEEL (54-420): 2.71e-73: 240: 18.47
+	Sp
		194818 RPN7_SCHPO (49-421): 2.61e-87: 273: 18.25		RPN3_SCHPO (51-424): 9.83e-87: 274: 18.09
+	Hs
		897237 CSN1_HUMAN (28-440): 1.81e-100: 310: 45.00		CSN2_HUMAN (33-384): 4.6e-73: 237: 11.17
+	At
		1338954 PSD11_ARATH (18-431): 1.02e-82: 262: 13.04		PSD11_ARATH (8-385): 8.2e-90: 280: 12.66
+	Zm
		6700 A0A1D6E9U1_MAIZE (60-431): 3.24e-85: 269: 13.98		A0A1D6E9U1_MAIZE (8-385): 5.3e-86: 270: 13.70
+	An
		1124315 CSN1_EMENI (6-436): 1.48e-98: 305: 35.62		CSN2_EMENI (37-374): 8.1e-70: 230: 12.43
+	Sp
		1013798 RPN7_SCHPO (49-421): 2.61e-87: 273: 18.25		RPN6_SCHPO (36-392): 1.31e-79: 253: 14.65
+	Sc
		766899 RPN6_YEAST (66-429): 1.84e-85: 270: 14.44		RPN3_YEAST (49-418): 1.79e-76: 248: 16.54
+	Ce
		136317 CSN1_CAEEL (13-440): 4.45e-80: 260: 24.69		CSN2_CAEEL (30-366): 1.13e-71: 235: 12.46
+	Sc
		1015535 RPN6_YEAST (66-429): 1.84e-85: 270: 14.44		RPN6_YEAST (51-386): 1.27e-62: 210: 12.11