HitPredict - High confidence protein-protein interactions

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	1.00	0.854

Property	Details
Experiments	11336697, 18716626, 21888893
Identification Methods	affinity chromatography technology, pull down, two hybrid, molecular sieving
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Chromo~Chromo, Chromo_shadow~Chromo_shadow
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0000776 - kinetochore GO:0000781 - chromosome, telomeric region GO:0000792 - heterochromatin and 21 others more... GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005635 - nuclear envelope GO:0005654 - nucleoplasm GO:0005721 - pericentric heterochromatin GO:0005730 - nucleolus GO:0006325 - chromatin organization GO:0006974 - DNA damage response GO:0010369 - chromocenter GO:0017053 - transcription repressor complex GO:0030674 - protein-macromolecule adaptor activity GO:0032991 - protein-containing complex GO:0035064 - methylated histone binding GO:0035097 - histone methyltransferase complex GO:0042826 - histone deacetylase binding GO:0043021 - ribonucleoprotein complex binding GO:0044877 - protein-containing complex binding GO:0045892 - negative regulation of DNA-templated transcription GO:0090734 - site of DNA damage GO:0140297 - DNA-binding transcription factor binding GO:1990904 - ribonucleoprotein complex
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1	191
Hs

1	191

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Last updated: 15 Jul 2024