HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: IMA1 (P52292)
Importin subunit alpha-1 (Karyopherin subunit alpha-2) (RAG cohort protein 1) (SRP1-alpha)
Gene: KPNA2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	20562864, 21888893
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0042826 - histone deacetylase binding
Homologous interactions	16

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 529
+	Hs
		134845 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		853239 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		IMA1_HUMAN (1-529): 6.78e-164: 477: 100.00
+	Hs
		131397 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Hs
		134888 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		134876 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		IMA3_HUMAN (4-529): 5.61e-152: 446: 50.38
+	Hs
		238666 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37
+	Hs
		131416 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		IMA4_HUMAN (4-529): 6.93e-148: 436: 49.06
+	Hs
		238657 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		IMA7_HUMAN (1-528): 1.97e-141: 420: 45.37
+	At
		1276955 LHP1_ARATH (13-104): 2.12e-16: 78: 33.68		IMPA1_ARATH (1-529): 3.69e-156: 457: 45.00
+	At
		984992 Q058P7_ARATH (13-104): 2.12e-16: 78: 33.68		IMPA1_ARATH (1-529): 3.69e-156: 457: 45.00
+	At
		97779 Q058P7_ARATH (13-104): 2.12e-16: 78: 33.68		IMPA2_ARATH (1-529): 1.12e-155: 456: 44.47
+	At
		97806 LHP1_ARATH (13-104): 2.12e-16: 78: 33.68		IMPA2_ARATH (1-529): 1.12e-155: 456: 44.47
+	At
		285377 Q058P7_ARATH (13-104): 2.12e-16: 78: 33.68		IMPA4_ARATH (1-529): 9.28e-155: 454: 43.57
+	At
		285382 LHP1_ARATH (13-104): 2.12e-16: 78: 33.68		IMPA4_ARATH (1-529): 9.28e-155: 454: 43.57
+	At
		1276959 LHP1_ARATH (13-104): 2.12e-16: 78: 33.68		IMPA6_ARATH (1-529): 1.15e-152: 448: 42.46
+	At
		984993 Q058P7_ARATH (13-104): 2.12e-16: 78: 33.68		IMPA6_ARATH (1-529): 1.15e-152: 448: 42.46