HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.84	0.60	0.714

Property	Details
Experiments	24981860, 33961781, 36089195, 17403666, 19834512
Identification Methods	affinity chromatography technology, proximity labelling technology, anti tag coimmunoprecipitation, nuclear magnetic resonance, pull down
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0032991 - protein-containing complex
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 136
+	Hs
		800341 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		800397 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Mm
		952749 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		800434 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Mm
		952259 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		H32_MOUSE (1-136): 5.32e-59: 180: 97.06
+	Hs
		934721 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952310 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Mm
		952771 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		1027017 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		1027078 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Mm
		952270 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		H32_MOUSE (1-136): 5.32e-59: 180: 97.06
+	Hs
		934657 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Mm
		935445 CBX1_MOUSE (26-180): 2.32e-55: 175: 60.65		H31_MOUSE (1-136): 3.08e-60: 183: 96.32
+	Hs
		949755 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Dm
		356124 Q9W396_DROME (19-175): 3.86e-55: 176: 50.96		H3_DROME (1-136): 5.32e-59: 180: 97.06
+	Hs
		949795 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		800317 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		949821 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Mm
		949929 CBX1_MOUSE (26-180): 2.32e-55: 175: 60.65		H32_MOUSE (1-136): 5.32e-59: 180: 97.06
+	Hs
		828217 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76