HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: H31T (Q16695)
Histone H3.1t (H3/t) (H3t) (H3/g) (Histone H3.4)
Gene: H3-4

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	20850016, 21047797, 21029866, 23281010, 17884155, 18404153, 30021884, 15306854, 23645696, 21888893
Identification Methods	affinity chromatography technology, unspecified method, x-ray crystallography, pull down, proximity labelling technology, cross-linking study, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 136
+	Hs
		800341 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		800347 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Hs
		800434 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		H32_HUMAN (1-136): 1.34e-60: 184: 96.32
+	Mm
		952749 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		H33_MOUSE (1-136): 4.53e-61: 185: 93.38
+	Mm
		952259 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		H32_MOUSE (1-136): 1.34e-60: 184: 96.32
+	Hs
		934721 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Hs
		1027017 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H31T_HUMAN (1-136): 2.65e-61: 186: 100.00
+	Hs
		952310 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Mm
		952771 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		H33_MOUSE (1-136): 4.53e-61: 185: 93.38
+	Hs
		1027078 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H32_HUMAN (1-136): 1.34e-60: 184: 96.32
+	Mm
		952270 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		H32_MOUSE (1-136): 1.34e-60: 184: 96.32
+	Hs
		934657 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H31_HUMAN (1-136): 6.88e-62: 187: 97.06
+	Mm
		935445 CBX1_MOUSE (26-180): 2.32e-55: 175: 60.65		H31_MOUSE (1-136): 6.88e-62: 187: 97.06
+	Hs
		949795 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H31T_HUMAN (1-136): 2.65e-61: 186: 100.00
+	Dm
		356124 Q9W396_DROME (19-175): 3.86e-55: 176: 50.96		H3_DROME (1-136): 1.34e-60: 184: 96.32
+	Hs
		949755 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H33_HUMAN (1-136): 4.53e-61: 185: 93.38
+	Hs
		949821 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H32_HUMAN (1-136): 1.34e-60: 184: 96.32
+	Mm
		949929 CBX1_MOUSE (26-180): 2.32e-55: 175: 60.65		H32_MOUSE (1-136): 1.34e-60: 184: 96.32
+	Hs
		800317 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		CENPA_HUMAN (9-133): 3.54e-44: 142: 49.24
+	Hs
		828217 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		CENPA_HUMAN (9-133): 3.54e-44: 142: 49.24