HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: NIPBL (Q6KC79)
Nipped-B-like protein (Delangin) (SCC2 homolog)
Gene: NIPBL

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.67	0.60	0.636

Property	Details
Experiments	15882967, 20562864
Identification Methods	unspecified method, affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006974 - DNA damage response and 1 others more... GO:0042826 - histone deacetylase binding
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 2804
+	Hs
		1027054 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		NIPBL_HUMAN (1-2804): 0: 2316: 100.00
+	Hs
		949814 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		NIPBL_HUMAN (1-2804): 0: 2316: 100.00
+	Dm
		399009 HP1_DROME (1-180): 3.46e-50: 162: 42.23		NIPB_DROME (982-2665): 0: 1451: 35.08
+	Hs
		1026998 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		MDC1_HUMAN (181-1278): 4.32e-26: 120: 8.91
+	Hs
		1027090 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		RBBP6_HUMAN (184-1314): 3.86e-22: 107: 12.45
+	Hs
		1027214 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		MINT_HUMAN (273-1226): 7.68e-22: 107: 13.49
+	Dm
		399075 HP1_DROME (1-180): 3.46e-50: 162: 42.23		Q9W3D1_DROME (594-1160): 9.81e-09: 63.4: 14.21
+	Hs
		1056829 CBX2_HUMAN (10-111): 5.1e-24: 99.9: 31.37		MDC1_HUMAN (181-1278): 4.32e-26: 120: 8.91