HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: Z280D (Q6N043)
Zinc finger protein 280D (Suppressor of hairy wing homolog 4) (Zinc finger protein 634)
Gene: ZNF280D

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.81	0.60	0.698

Property	Details
Experiments	27705803, 32296183, 20562864, unassigned1304
Identification Methods	affinity chromatography technology, two hybrid, two hybrid array, validated two hybrid, two hybrid prey pooling approach, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 979
+	Hs
		64135 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN729_HUMAN (29-831): 0: 699: 12.80
+	Hs
		64140 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZN729_HUMAN (29-831): 0: 699: 12.80
+	Mm
		1143024 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		Z280D_MOUSE (2-979): 0: 568: 75.97
+	Hs
		800470 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z280C_HUMAN (3-734): 3.44e-174: 527: 67.39
+	Mm
		1143025 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		Z280C_MOUSE (10-738): 6.7e-166: 505: 61.91
+	Mm
		1143032 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		POGZ_MOUSE (26-830): 2.25e-152: 489: 32.02
+	Hs
		800440 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		POGZ_HUMAN (26-831): 6.14e-141: 458: 31.97
+	Hs
		67424 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZN850_HUMAN (31-500): 1.26e-145: 463: 13.92
+	Hs
		800425 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z585A_HUMAN (443-910): 4.79e-101: 335: 9.88
+	Hs
		800409 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN569_HUMAN (504-964): 1.93e-99: 329: 8.28
+	Hs
		728565 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZNF93_HUMAN (470-911): 3.11e-106: 345: 11.46
+	Hs
		64158 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN726_HUMAN (542-911): 6.74e-82: 279: 10.07
+	Hs
		800493 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN479_HUMAN (222-508): 9.19e-39: 154: 20.69
+	Hs
		549158 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZN250_HUMAN (222-506): 9.83e-38: 151: 20.71
+	Hs
		800402 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN568_HUMAN (34-185): 1.81e-31: 133: 11.18
+	Hs
		800406 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z585B_HUMAN (712-911): 3.3e-30: 130: 7.54
+	Hs
		58857 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		A2VDJ6_HUMAN (321-505): 5.24e-30: 127: 26.15
+	Hs
		67855 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN724_HUMAN (32-186): 2.52e-28: 123: 10.32
+	Hs
		800399 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN829_HUMAN (313-412): 1e-10: 66.9: 20.49
+	Hs
		258850 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		Z780A_HUMAN (714-879): 3.18e-10: 66: 8.14