HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: H32 (Q71DI3)
Histone H3.2 (H3-clustered histone 13) (H3-clustered histone 14) (H3-clustered histone 15) (Histone H3/m) (Histone H3/o)
Gene: H3C15

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.72	0.60	0.660

Property	Details
Experiments	11336697, 24981860, 37071682
Identification Methods	pull down, affinity chromatography technology, cross-linking study, tandem affinity purification
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 136
+	Hs
		800341 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		800397 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		800347 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Mm
		952259 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		H32_MOUSE (1-136): 3.73e-61: 186: 100.00
+	Mm
		952749 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		934721 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Hs
		1027017 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		1027078 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Mm
		952270 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		H32_MOUSE (1-136): 3.73e-61: 186: 100.00
+	Hs
		952310 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Mm
		952771 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		H33_MOUSE (1-136): 1.59e-61: 186: 97.06
+	Hs
		934657 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H31_HUMAN (1-136): 1.98e-62: 189: 99.27
+	Mm
		935445 CBX1_MOUSE (26-180): 2.32e-55: 175: 60.65		H31_MOUSE (1-136): 1.98e-62: 189: 99.27
+	Dm
		356124 Q9W396_DROME (19-175): 3.86e-55: 176: 50.96		H3_DROME (1-136): 3.73e-61: 186: 100.00
+	Hs
		949795 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H31T_HUMAN (1-136): 8.3e-62: 187: 96.32
+	Hs
		949755 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H33_HUMAN (1-136): 1.59e-61: 186: 97.06
+	Hs
		949821 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		H32_HUMAN (1-136): 3.73e-61: 186: 100.00
+	Mm
		949929 CBX1_MOUSE (26-180): 2.32e-55: 175: 60.65		H32_MOUSE (1-136): 3.73e-61: 186: 100.00
+	Hs
		800317 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00
+	Hs
		828217 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		CENPA_HUMAN (9-133): 2.85e-44: 143: 50.00