HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: POGZ (Q7Z3K3)
Pogo transposable element with ZNF domain (Suppressor of hairy wing homolog 5) (Zinc finger protein 280E) (Zinc finger protein 635)
Gene: POGZ

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.87	0.60	0.723

Property	Details
Experiments	20850016, 27705803, 24981860, 20562864, 19498464
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, tandem affinity purification
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1410
+	Mm
		1143032 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		POGZ_MOUSE (1-1410): 0: 836: 93.14
+	Hs
		800422 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z280D_HUMAN (133-858): 0: 654: 35.47
+	Mm
		1143024 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		Z280D_MOUSE (147-857): 0: 606: 35.56
+	Hs
		64135 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN729_HUMAN (463-1158): 0: 582: 12.13
+	Hs
		64140 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZN729_HUMAN (463-1158): 0: 582: 12.13
+	Hs
		800470 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z280C_HUMAN (148-858): 3.19e-175: 541: 33.33
+	Mm
		1143025 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		Z280C_MOUSE (133-866): 9.84e-162: 506: 31.73
+	Hs
		64158 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN726_HUMAN (419-896): 2.25e-146: 461: 15.50
+	Hs
		67424 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZN850_HUMAN (627-1159): 1.17e-143: 469: 11.29
+	Hs
		800410 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN678_HUMAN (394-789): 3.05e-112: 366: 20.55
+	Hs
		800409 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN569_HUMAN (799-1159): 1.22e-102: 345: 7.14
+	Hs
		563302 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZNF16_HUMAN (526-1037): 5.66e-85: 294: 11.65
+	Hs
		67855 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN724_HUMAN (281-481): 4.81e-47: 181: 13.33
+	Hs
		800402 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN568_HUMAN (331-522): 8.82e-28: 123: 14.88
+	Hs
		800350 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZNF45_HUMAN (945-1115): 3.41e-20: 99: 12.62
+	Hs
		800406 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z585B_HUMAN (74-199): 7.61e-17: 88.6: 9.52
+	Hs
		800425 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z585A_HUMAN (74-199): 1.31e-16: 87.8: 8.73
+	Hs
		800399 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN829_HUMAN (474-678): 1.01e-10: 67.8: 26.54
+	Hs
		800500 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZIM3_HUMAN (477-676): 1.5e-10: 67.4: 27.23
+	Hs
		800447 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN227_HUMAN (726-897): 9.82e-09: 62.1: 9.30