HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: ZN274 (Q96GC6)
Neurotrophin receptor-interacting factor homolog (Zinc finger protein 274) (Zinc finger protein HFB101) (Zinc finger protein with KRAB and SCAN domains 19) (Zinc finger protein zfp2) (Zf2)
Gene: ZNF274

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	20562864
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0003682 - chromatin binding GO:0005730 - nucleolus
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 653
+	Hs
		67424 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZN850_HUMAN (55-613): 1.39e-165: 504: 15.82
+	Hs
		64135 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN729_HUMAN (55-600): 8.73e-152: 472: 15.27
+	Hs
		64140 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZN729_HUMAN (55-600): 8.73e-152: 472: 15.27
+	Hs
		258850 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		Z780A_HUMAN (332-652): 5.49e-127: 391: 27.10
+	Hs
		800474 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN483_HUMAN (359-652): 3.17e-99: 321: 29.81
+	Hs
		800409 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN569_HUMAN (55-447): 7.36e-96: 311: 7.03
+	Hs
		67855 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN724_HUMAN (61-424): 4.76e-86: 283: 6.30
+	Hs
		64158 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN726_HUMAN (284-653): 6.1e-83: 275: 29.46
+	Hs
		800406 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z585B_HUMAN (55-301): 6.29e-35: 143: 6.72
+	Hs
		161795 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN263_HUMAN (322-531): 1.2e-32: 135: 18.86
+	Hs
		161822 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZN263_HUMAN (322-531): 1.2e-32: 135: 18.86
+	Hs
		800350 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZNF45_HUMAN (54-263): 5e-18: 90.4: 9.55
+	Hs
		565107 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZNF8_HUMAN (6-104): 9.28e-16: 82.8: 47.06
+	Hs
		800425 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		Z585A_HUMAN (55-245): 6.58e-14: 77.3: 9.14
+	Hs
		599068 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZNF10_HUMAN (1-86): 1.16e-18: 92: 55.81
+	Hs
		800481 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN566_HUMAN (12-85): 3.87e-12: 70.5: 47.30
+	Hs
		800402 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN568_HUMAN (55-224): 1.57e-11: 69.6: 5.59
+	Hs
		800399 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		ZN829_HUMAN (1-77): 1.33e-11: 68.9: 50.65
+	Hs
		565115 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		ZNF8_HUMAN (6-104): 9.28e-16: 82.8: 47.06
+	Hs
		240839 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		Z354A_HUMAN (552-653): 7.55e-09: 60.9: 25.49