HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: EHMT2 (Q96KQ7)
Histone-lysine N-methyltransferase EHMT2 (EC 2.1.1.-) (EC 2.1.1.367) (Euchromatic histone-lysine N-methyltransferase 2) (HLA-B-associated transcript 8) (Histone H3-K9 methyltransferase 3) (H3-K9-HMTase 3) (Lysine N-methyltransferase 1C) (Protein G9a)
Gene: EHMT2

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.696

Property	Details
Experiments	24981860, 20562864, 17962312, 15200951
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1210
+	Hs
		1027194 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		EHMT2_HUMAN (21-1210): 0: 909: 100.00
+	Hs
		949863 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		EHMT2_HUMAN (21-1210): 0: 909: 100.00
+	Mm
		1143050 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		EHMT2_MOUSE (9-1210): 0: 870: 94.44
+	Mm
		1322180 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		EHMT2_MOUSE (9-1210): 0: 870: 94.44
+	Hs
		800530 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		EHMT1_HUMAN (1-1209): 0: 685: 45.63
+	Mm
		1125433 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		EHMT1_MOUSE (1-1209): 0: 692: 45.04
+	Hs
		1027268 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		EHMT1_HUMAN (1-1209): 0: 685: 45.63
+	Dm
		115794 Q9W396_DROME (19-175): 3.86e-55: 176: 50.96		M9PGH7_DROME (1-1210): 5.56e-155: 507: 23.23
+	Hs
		1331984 V9HWG0_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Hs
		800527 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Mm
		222467 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		SUV91_MOUSE (863-1177): 5.92e-84: 281: 30.95
+	Hs
		1027262 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		SUV92_HUMAN (928-1177): 2.53e-85: 285: 35.93
+	Hs
		203638 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Hs
		203823 V9HWG0_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Mm
		222468 Q9DCC5_MOUSE (1-181): 3.06e-62: 192: 60.22		SUV91_MOUSE (863-1177): 5.92e-84: 281: 30.95
+	Mm
		222460 CBX3_MOUSE (1-181): 6.23e-62: 191: 60.22		SUV91_MOUSE (863-1177): 5.92e-84: 281: 30.95
+	Mm
		613035 CBX3_MOUSE (1-181): 6.23e-62: 191: 60.22		SUV92_MOUSE (928-1177): 5.95e-82: 278: 36.30
+	Hs
		203674 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Hs
		203662 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		SUV91_HUMAN (861-1179): 1.67e-78: 266: 30.51
+	Dm
		800674 Q9W396_DROME (19-175): 3.86e-55: 176: 50.96		SUV39_DROME (934-1176): 1.28e-28: 125: 36.84