HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: NSD3 (Q9BZ95)
Histone-lysine N-methyltransferase NSD3 (EC 2.1.1.370) (EC 2.1.1.371) (Nuclear SET domain-containing protein 3) (Protein whistle) (WHSC1-like 1 isoform 9 with methyltransferase activity to lysine) (Wolf-Hirschhorn syndrome candidate 1-like protein 1) (WHSC1-like protein 1)
Gene: NSD3

Species: Homo sapiens

Source: mint

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.74	0.60	0.669

Property	Details
Experiments	25416956, 21516116, 32814053
Identification Methods	two hybrid, two hybrid array, two hybrid pooling approach, validated two hybrid, luminescence based mammalian interactome mapping
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 191 Hs			1 1437
+	Hs
		1317731 V9HWG0_HUMAN (1-191): 1.24e-68: 209: 100.00		NSD3_HUMAN (1-1437): 0: 1169: 100.00
+	Hs
		1027243 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		NSD3_HUMAN (1-1437): 0: 1169: 100.00
+	Hs
		331801 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		NSD2_HUMAN (140-1414): 0: 825: 45.08
+	Hs
		1331984 V9HWG0_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV92_HUMAN (903-1285): 1.04e-77: 265: 23.22
+	Hs
		800527 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV92_HUMAN (903-1285): 1.04e-77: 265: 23.22
+	Hs
		203638 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		203823 V9HWG0_HUMAN (1-191): 1.24e-68: 209: 100.00		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		1027262 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		SUV92_HUMAN (903-1285): 1.04e-77: 265: 23.22
+	Mm
		222467 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		SUV91_MOUSE (904-1285): 3.8e-72: 249: 22.56
+	Hs
		203674 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		SUV91_HUMAN (904-1285): 4e-73: 252: 22.56
+	Hs
		800497 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		800516 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		800530 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		800391 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		EZH2_HUMAN (1076-1270): 1.53e-58: 218: 28.78
+	Mm
		1142272 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		EZH2_MOUSE (1076-1270): 1.26e-58: 218: 28.78
+	Hs
		1027194 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		EHMT2_HUMAN (1029-1281): 2.28e-60: 229: 22.84
+	Hs
		1027242 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		SETD2_HUMAN (1004-1320): 1.62e-59: 228: 32.18
+	Hs
		1027268 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		EHMT1_HUMAN (995-1301): 1.89e-59: 227: 20.54
+	Hs
		975237 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		KMT2A_HUMAN (1131-1285): 7.1e-40: 164: 30.13
+	Hs
		1027195 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		NSD1_HUMAN (91-724): 2.53e-28: 126: 15.30