HitPredict

Interactor 1: CBX5 (P45973)
Chromobox protein homolog 5 (Antigen p25) (Heterochromatin protein 1 homolog alpha) (HP1 alpha)
Gene: CBX5

Interactor 2: INCE (Q9NQS7)
Inner centromere protein
Gene: INCENP

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.78	0.60	0.685

Property	Details
Experiments	20562864, 21346195, 9864353
Identification Methods	affinity chromatography technology, two hybrid, anti tag coimmunoprecipitation, anti bait coimmunoprecipitation, pull down
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000776 - kinetochore GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005721 - pericentric heterochromatin GO:0010369 - chromocenter and 1 others more... GO:0032991 - protein-containing complex
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 191 Hs			1 918
+	Mm
		1143049 CBX5_MOUSE (1-191): 1.9e-68: 208: 97.91		INCE_MOUSE (1-910): 5.02e-68: 246: 62.98
+	Hs
		800421 CBX5_HUMAN (1-191): 1.24e-68: 209: 100.00		NIPBL_HUMAN (27-674): 3.82e-59: 223: 14.47
+	Hs
		1027054 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		NIPBL_HUMAN (27-674): 3.82e-59: 223: 14.47
+	Hs
		1027281 CBX3_HUMAN (1-181): 3.06e-62: 192: 60.22		INCE_HUMAN (1-918): 8.99e-57: 213: 100.00
+	Hs
		949814 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		NIPBL_HUMAN (27-674): 3.82e-59: 223: 14.47
+	Hs
		949893 CBX1_HUMAN (26-180): 2.32e-55: 175: 60.65		INCE_HUMAN (1-918): 8.99e-57: 213: 100.00
+	Hs
		1329365 SUV92_HUMAN (3-134): 5.96e-33: 123: 24.64		SLK_HUMAN (76-821): 3.53e-17: 89.1: 12.09