HitPredict

Interactor 1: UBP5 (P45974)
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)
Gene: USP5

Interactor 2: TRAF6 (Q9Y4K3)
TNF receptor-associated factor 6 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF6) (Interleukin-1 signal transducer) (RING finger protein 85) (RING-type E3 ubiquitin transferase TRAF6)
Gene: TRAF6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	32214906, 20622874
Identification Methods	affinity chromatography technology, enzymatic study
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0008270 - zinc ion binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 858 Hs			1 522
+	Hs
		800581 UBP5_HUMAN (1-858): 0: 842: 100.00		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		800578 UBP5_HUMAN (1-858): 0: 842: 100.00		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		800627 UBP5_HUMAN (1-858): 0: 842: 100.00		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		1273989 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		1121220 UBP39_HUMAN (133-660): 1.38e-83: 280: 14.87		TRAF6_HUMAN (1-522): 1.12e-151: 445: 100.00
+	Hs
		1020848 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRAF2_HUMAN (40-500): 7.2e-101: 314: 25.85
+	Hs
		1273839 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRAF4_HUMAN (54-500): 6.36e-91: 287: 26.11
+	Hs
		129585 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRAF5_HUMAN (43-500): 4.95e-87: 280: 25.23
+	Hs
		1024726 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRAF3_HUMAN (19-501): 9.91e-86: 277: 22.18
+	Hs
		1023747 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRAF1_HUMAN (50-501): 5.58e-64: 216: 19.40
+	Hs
		1273788 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI11_HUMAN (59-404): 1.13e-49: 179: 12.75
+	Hs
		1052677 UBP39_HUMAN (133-660): 1.38e-83: 280: 14.87		TRI25_HUMAN (63-370): 4.93e-45: 169: 18.61
+	Hs
		1019375 UBP36_HUMAN (250-817): 9.73e-85: 295: 13.61		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		536961 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI27_HUMAN (57-404): 7.01e-43: 161: 12.90
+	Hs
		1223388 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI22_HUMAN (56-361): 5.96e-39: 150: 15.51
+	Hs
		1019313 UBP39_HUMAN (133-660): 1.38e-83: 280: 14.87		TRI26_HUMAN (61-410): 2.85e-38: 149: 14.59
+	Hs
		1121195 UBP39_HUMAN (133-660): 1.38e-83: 280: 14.87		TRIM5_HUMAN (56-315): 8.46e-38: 147: 16.11
+	Hs
		1273857 UBP7_HUMAN (247-777): 7.21e-80: 281: 13.17		TRI31_HUMAN (58-334): 3.02e-35: 138: 15.00
+	Hs
		1252377 USP9X_HUMAN (289-758): 2.24e-84: 298: 16.20		LNX1_HUMAN (58-183): 2.59e-11: 68.3: 19.84
+	Mm
		1193545 UBP8_MOUSE (270-649): 1.18e-71: 257: 19.34		RNF41_MOUSE (55-177): 2.68e-17: 84.9: 33.33