HitPredict

Interactor 1: SUV39 (P45975)
Histone-lysine N-methyltransferase Su(var)3-9 (EC 2.1.1.355) (Histone H3-K9 methyltransferase) (H3-K9-HMTase) (Lysine N-methyltransferase 1) (Protein suppressor of variegation 3-9)
Gene: Su(var)3-9

Interactor 2: HDAC1 (Q94517)
Histone deacetylase HDAC1 (HD) (EC 3.5.1.98)
Gene: HDAC1

Species: Drosophila melanogaster

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.624

Property	Details
Experiments	11571273, 20386606
Identification Methods	affinity chromatography technology, coimmunoprecipitation
Interaction Type	physical association, methylation reaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0006325 - chromatin organization GO:0031507 - heterochromatin formation GO:0048477 - oogenesis GO:2001229 - negative regulation of response to gamma radiation
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 635 Dm			1 521
+	Hs
		203750 SUV91_HUMAN (209-635): 2.01e-111: 342: 33.33		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Mm
		222461 SUV91_MOUSE (209-635): 4.87e-109: 336: 33.33		HDAC2_MOUSE (2-488): 0: 655: 76.18
+	Hs
		203679 SUV91_HUMAN (209-635): 2.01e-111: 342: 33.33		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Mm
		140205 SUV91_MOUSE (209-635): 4.87e-109: 336: 33.33		HDAC1_MOUSE (3-443): 0: 640: 81.18
+	Hs
		1270381 EHMT2_HUMAN (311-631): 2.44e-89: 303: 29.48		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		1270450 EHMT1_HUMAN (336-631): 1.62e-84: 290: 30.90		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Hs
		1038631 EHMT2_HUMAN (311-631): 2.44e-89: 303: 29.48		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Hs
		1038721 EHMT1_HUMAN (336-631): 1.62e-84: 290: 30.90		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Dm
		785632 EZ_DROME (304-621): 1.37e-73: 253: 21.69		HDAC1_DROME (1-521): 0: 674: 100.00
+	Hs
		177134 SUV91_HUMAN (209-635): 2.01e-111: 342: 33.33		HDAC3_HUMAN (6-427): 0: 572: 56.37
+	Mm
		222457 SUV91_MOUSE (209-635): 4.87e-109: 336: 33.33		HDAC3_MOUSE (6-427): 0: 573: 56.60
+	Hs
		1080187 EZH2_HUMAN (321-622): 3.92e-69: 240: 22.36		HDAC2_HUMAN (2-488): 0: 659: 76.59
+	Mm
		936404 Q6AXH7_MOUSE (321-622): 2.33e-68: 238: 22.05		HDAC2_MOUSE (2-488): 0: 655: 76.18
+	Mm
		140274 EZH2_MOUSE (321-622): 1.34e-68: 239: 22.05		HDAC1_MOUSE (3-443): 0: 640: 81.18
+	Hs
		1038412 EZH2_HUMAN (321-622): 3.92e-69: 240: 22.36		HDAC1_HUMAN (3-443): 0: 637: 81.18
+	Mm
		140296 NSD2_MOUSE (328-634): 7.85e-66: 237: 23.40		HDAC1_MOUSE (3-443): 0: 640: 81.18
+	Hs
		177306 EZH2_HUMAN (321-622): 3.92e-69: 240: 22.36		HDAC3_HUMAN (6-427): 0: 572: 56.37
+	Hs
		203653 SUV91_HUMAN (209-635): 2.01e-111: 342: 33.33		HDAC4_HUMAN (5-405): 2.08e-133: 415: 22.86
+	Sc
		755785 SET1_YEAST (245-634): 3.28e-67: 239: 18.69		HOS2_YEAST (8-409): 1.15e-168: 486: 50.48
+	Hs
		880741 EZH2_HUMAN (321-622): 3.92e-69: 240: 22.36		HDAC4_HUMAN (5-405): 2.08e-133: 415: 22.86