HitPredict

Interactor 1: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Interactor 2: RAC1 (P63000)
Ras-related C3 botulinum toxin substrate 1 (EC 3.6.5.2) (Cell migration-inducing gene 5 protein) (Ras-like protein TC25) (p21-Rac1)
Gene: RAC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	25284480
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	Pkinase~Ras
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0019899 - enzyme binding
Homologous interactions	7

Homologous interactions

Color coding for hit scores

	1 427 Hs			1 192
+	Mm
		925825 MK09_MOUSE (1-427): 1.29e-160: 460: 81.50		RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00
+	Hs
		800740 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		CDC42_HUMAN (1-192): 1.4e-78: 234: 70.31
+	Hs
		800741 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		RHOA_HUMAN (5-192): 3.5e-77: 230: 57.98
+	Mm
		925813 MK08_MOUSE (1-381): 7.75e-152: 437: 99.48		RAC1_MOUSE (1-192): 3.81e-86: 253: 100.00
+	Hs
		625333 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		RAC1_HUMAN (1-192): 3.81e-86: 253: 100.00
+	Hs
		436162 CDK2_HUMAN (23-329): 1.82e-136: 394: 33.23		RHOC_HUMAN (5-192): 8.68e-75: 224: 57.45
+	Rn
		926512 MK01_RAT (20-359): 2.95e-84: 263: 42.98		RAC1_RAT (1-192): 3.81e-86: 253: 100.00