HitPredict

Interactor 1: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Interactor 2: DUS4 (Q13115)
Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)
Gene: DUSP4

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.878

Property	Details
Experiments	19843478, 28675297, 11387337, 16038800
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	DSPc~Pkinase, Pkinase~Rhodanese
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 427 Hs			1 394
+	Hs
		800878 MK09_HUMAN (1-427): 5.18e-163: 467: 80.80		DUS4_HUMAN (1-394): 1.2e-160: 458: 100.00
+	Hs
		659258 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		DUS1_HUMAN (24-394): 8.5e-134: 389: 62.53
+	Hs
		659264 MK10_HUMAN (1-427): 6.5e-163: 468: 90.16		DUS1_HUMAN (24-394): 8.5e-134: 389: 62.53
+	Hs
		659259 MK09_HUMAN (1-427): 5.18e-163: 467: 80.80		DUS1_HUMAN (24-394): 8.5e-134: 389: 62.53
+	Hs
		800827 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		DUS16_HUMAN (23-393): 8.39e-108: 332: 29.55
+	Hs
		864875 MK10_HUMAN (1-427): 6.5e-163: 468: 90.16		DUS16_HUMAN (23-393): 8.39e-108: 332: 29.55
+	Hs
		800938 MK09_HUMAN (1-427): 5.18e-163: 467: 80.80		DUS16_HUMAN (23-393): 8.39e-108: 332: 29.55
+	Hs
		659285 MK11_HUMAN (4-363): 2.3e-137: 399: 47.11		DUS1_HUMAN (24-394): 8.5e-134: 389: 62.53
+	Mm
		985169 MK09_MOUSE (1-427): 1.29e-160: 460: 81.50		DUS2_MOUSE (4-335): 1.05e-110: 328: 47.02
+	Hs
		800770 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		DUS8_HUMAN (19-349): 1.14e-97: 305: 31.74
+	Hs
		800879 MK09_HUMAN (1-427): 5.18e-163: 467: 80.80		DUS8_HUMAN (19-349): 1.14e-97: 305: 31.74
+	Hs
		800856 MK08_HUMAN (1-427): 6.2e-164: 469: 100.00		DUS10_HUMAN (40-353): 1.76e-90: 282: 29.25
+	Hs
		864881 MK10_HUMAN (1-427): 6.5e-163: 468: 90.16		DUS10_HUMAN (40-353): 1.76e-90: 282: 29.25
+	Hs
		800968 MK09_HUMAN (1-427): 5.18e-163: 467: 80.80		DUS10_HUMAN (40-353): 1.76e-90: 282: 29.25
+	Hs
		985177 MK11_HUMAN (4-363): 2.3e-137: 399: 47.11		DUS2_HUMAN (4-335): 1.68e-113: 335: 47.02
+	Hs
		864874 MK10_HUMAN (1-427): 6.5e-163: 468: 90.16		DUS9_HUMAN (34-368): 1.12e-82: 259: 31.22
+	Mm
		1265206 MK08_MOUSE (1-381): 7.75e-152: 437: 99.48		DUS10_MOUSE (40-353): 4.91e-92: 286: 29.56
+	Hs
		304933 MK09_HUMAN (1-427): 5.18e-163: 467: 80.80		DUS14_HUMAN (176-359): 1.96e-71: 224: 33.15
+	Hs
		800927 MK09_HUMAN (1-427): 5.18e-163: 467: 80.80		DUS19_HUMAN (174-347): 8.88e-59: 192: 33.33
+	Hs
		1078199 MK11_HUMAN (4-363): 2.3e-137: 399: 47.11		DUS9_HUMAN (34-368): 1.12e-82: 259: 31.22