Interactor 1: MK08 (P45983)
Mitogen-activated protein kinase 8 (MAP kinase 8) (MAPK 8) (EC 2.7.11.24) (JNK-46) (Stress-activated protein kinase 1c) (SAPK1c) (Stress-activated protein kinase JNK1) (c-Jun N-terminal kinase 1)
Gene: MAPK8

Interactor 2: M3K4 (Q9Y6R4)
Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4)
Gene: MAP3K4

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.58 1.00 0.768

The method score is based on:

Property Details
Experiments 26496610, 21152872
Identification Methods affinity chromatography technology, enzymatic study
Interaction Type physical association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains Pkinase~Pkinase
Common GO terms GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0106310 - protein serine kinase activity
Homologous interactions 16

Homologous interactions

Color coding for hit scores

1 427
Hs

1 1608
+ Hs
+ Mm
+ Hs
+ Hs
+ Dm
+ Hs
+ At
+ Hs
+ At
+ Rn
+ Hs
+ Hs
+ Hs
+ Hs
+ At
+ Rn

Service provided by Combinatics, Japan

Last updated: 15 Jul 2024