HitPredict

Interactor 1: KI67 (P46013)
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
Gene: MKI67

Interactor 2: KMT2A (Q03164)
Histone-lysine N-methyltransferase 2A (Lysine N-methyltransferase 2A) (EC 2.1.1.364) (ALL-1) (CXXC-type zinc finger protein 7) (Cysteine methyltransferase KMT2A) (EC 2.1.1.-) (Myeloid/lymphoid or mixed-lineage leukemia) (Myeloid/lymphoid or mixed-lineage leukemia protein 1) (Trithorax-like protein) (Zinc finger protein HRX) [Cleaved into: MLL cleavage product N320 (N-terminal cleavage product of 320 kDa) (p320); MLL cleavage product C180 (C-terminal cleavage product of 180 kDa) (p180)]
Gene: KMT2A

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	34349018
Identification Methods	cross-linking study
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3256 Hs			1 3969
+	Hs
		975287 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		KMT2A_HUMAN (1-3969): 0: 3187: 100.00
+	Hs
		801165 KI67_HUMAN (1-3256): 0: 1046: 100.00		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		331740 KI67_HUMAN (1-3256): 0: 1046: 100.00		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		165645 KI67_HUMAN (1-3256): 0: 1046: 100.00		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		801326 KI67_HUMAN (1-3256): 0: 1046: 100.00		MINT_HUMAN (418-1102): 7.18e-09: 64.7: 11.18
+	Hs
		152608 KI67_HUMAN (1-3256): 0: 1046: 100.00		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47
+	Hs
		807879 MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		807738 MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Hs
		1056971 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		SETD2_HUMAN (3398-3968): 1.14e-75: 285: 16.61
+	Hs
		331812 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		331745 MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59		NSD2_HUMAN (3752-3968): 7.27e-60: 231: 27.23
+	Hs
		1244252 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		KMT2B_HUMAN (3163-3969): 3.56e-127: 454: 36.71
+	Hs
		820995 PRC2A_HUMAN (513-2601): 5.1e-21: 104: 7.93		EZH1_HUMAN (3468-3951): 2.87e-107: 364: 18.29
+	Hs
		1080130 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		EZH2_HUMAN (3450-3951): 9.4e-105: 357: 18.54
+	Dm
		1376672 FUTSC_DROME (52-3253): 3.26e-81: 303: 9.16		FUTSC_DROME (736-1358): 3.26e-10: 69.1: 12.74
+	Hs
		1244253 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		SET1B_HUMAN (3529-3969): 1.64e-66: 254: 27.12
+	Hs
		1244240 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		NSD3_HUMAN (3750-3968): 2.19e-56: 220: 25.68
+	Hs
		165700 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		SET1A_HUMAN (3695-3969): 8.18e-56: 218: 34.58
+	Hs
		1243827 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		KMT2C_HUMAN (384-1407): 6.81e-11: 71.4: 10.23
+	Hs
		152668 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		KMT2D_HUMAN (11-1393): 8.17e-09: 64.4: 10.47