HitPredict

Interactor 1: KI67 (P46013)
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
Gene: MKI67

Interactor 2: SRSF5 (Q13243)
Serine/arginine-rich splicing factor 5 (Delayed-early protein HRS) (Pre-mRNA-splicing factor SRP40) (Splicing factor, arginine/serine-rich 5)
Gene: SRSF5

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26949251
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005654 - nucleoplasm GO:0005730 - nucleolus
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 3256 Hs			1 272
+	Hs
		801101 KI67_HUMAN (1-3256): 0: 1046: 100.00		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		801115 KI67_HUMAN (1-3256): 0: 1046: 100.00		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		680426 KI67_HUMAN (1-3256): 0: 1046: 100.00		TIA1_HUMAN (2-101): 1.95e-12: 68.6: 16.67
+	Hs
		801083 KI67_HUMAN (1-3256): 0: 1046: 100.00		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		992772 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		1028547 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		SRSF9_HUMAN (2-211): 1.47e-52: 172: 33.02
+	Hs
		992995 SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53		SRSF1_HUMAN (2-170): 6.55e-57: 184: 43.68
+	Hs
		1028876 SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53		SRSF5_HUMAN (1-240): 2.63e-54: 178: 100.00
+	Hs
		993872 SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53		SRSF4_HUMAN (5-265): 3.78e-51: 176: 53.64
+	Hs
		1029163 SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53		SRSF6_HUMAN (5-184): 1.35e-48: 165: 61.96
+	Hs
		820908 PRC2A_HUMAN (513-2601): 5.1e-21: 104: 7.93		PABP4_HUMAN (104-189): 3.45e-16: 80.1: 21.98
+	Hs
		516406 PRC2A_HUMAN (513-2601): 5.1e-21: 104: 7.93		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		516749 SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		820889 PRC2A_HUMAN (513-2601): 5.1e-21: 104: 7.93		TIAR_HUMAN (3-103): 3.49e-12: 67.4: 14.56
+	Hs
		1031405 TITIN_HUMAN (52-1221): 1.55e-13: 80: 7.85		PABP4_HUMAN (104-189): 3.45e-16: 80.1: 21.98
+	Hs
		952179 SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53		SRSF3_HUMAN (4-78): 1.85e-11: 62.8: 47.56
+	Hs
		516609 TITIN_HUMAN (52-1221): 1.55e-13: 80: 7.85		PABP1_HUMAN (98-189): 1.16e-15: 78.6: 18.56
+	Hs
		965152 ANK2_HUMAN (926-3188): 1.69e-11: 73.2: 13.47		PABP3_HUMAN (98-189): 8.72e-15: 75.9: 18.56