HitPredict

Interactor 1: KI67 (P46013)
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
Gene: MKI67

Interactor 2: MDC1 (Q14676)
Mediator of DNA damage checkpoint protein 1 (Nuclear factor with BRCT domains 1)
Gene: MDC1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	22990118
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	FHA~FHA
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0005694 - chromosome GO:0016604 - nuclear body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 3256 Hs			1 2089
+	Hs
		801197 KI67_HUMAN (1-3256): 0: 1046: 100.00		NIPBL_HUMAN (869-1889): 2.17e-21: 104: 15.13
+	Hs
		801326 KI67_HUMAN (1-3256): 0: 1046: 100.00		MINT_HUMAN (159-1473): 1.72e-10: 68.9: 10.33
+	Hs
		1056827 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		1056897 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		MDC1_HUMAN (1-2089): 0: 665: 100.00
+	Hs
		1018956 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		TP53B_HUMAN (166-1970): 5.58e-75: 280: 8.87
+	Mm
		936732 MDC1_MOUSE (20-1501): 5.39e-78: 291: 9.51		TP53B_MOUSE (181-1970): 1.84e-92: 337: 10.07
+	Hs
		801012 MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59		KI67_HUMAN (38-1868): 2.43e-65: 249: 11.53
+	Hs
		1056872 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Dm
		1376672 FUTSC_DROME (52-3253): 3.26e-81: 303: 9.16		FUTSC_DROME (102-1944): 3.69e-41: 170: 8.41
+	Hs
		807793 MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59		PRG4_HUMAN (260-1225): 4.33e-17: 90.5: 9.80
+	Hs
		807690 MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59		ANK2_HUMAN (608-1849): 1.3e-11: 72.7: 10.40
+	Hs
		1173189 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Hs
		1173280 SRRM2_HUMAN (1748-3241): 1.64e-18: 96: 8.53		PAXI1_HUMAN (1840-2081): 6.55e-55: 212: 27.56
+	Dm
		65570 A8JNM5_DROME (676-2679): 9.04e-14: 80.5: 13.97		FUTSC_DROME (102-1944): 3.69e-41: 170: 8.41
+	Dm
		115305 M9PEP8_DROME (46-3246): 2.77e-39: 165: 7.95		TITIN_DROME (757-1667): 2e-11: 72: 12.37
+	Hs
		1303336 MUC4_HUMAN (409-3101): 1.78e-16: 89.4: 12.06		MUC4_HUMAN (143-1535): 2.62e-31: 137: 12.14
+	Hs
		1264771 TITIN_HUMAN (52-1221): 1.55e-13: 80: 7.85		TITIN_HUMAN (175-1895): 2.81e-32: 141: 8.72
+	Hs
		821099 PRC2A_HUMAN (513-2601): 5.1e-21: 104: 7.93		PRC2C_HUMAN (145-1944): 8.04e-16: 86.5: 8.07
+	Dm
		113976 M9PB30_DROME (2247-3103): 1.53e-18: 96.6: 7.31		M9PB30_DROME (131-695): 8.03e-11: 70.2: 6.81
+	Mm
		1351630 PCLO_MOUSE (102-1632): 2.96e-12: 75.4: 7.42		PCLO_MOUSE (75-1749): 3.3e-11: 71.5: 7.45