HitPredict

Interactor 1: KI67 (P46013)
Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)
Gene: MKI67

Interactor 2: EZH2 (Q15910)
Histone-lysine N-methyltransferase EZH2 (EC 2.1.1.356) (ENX-1) (Enhancer of zeste homolog 2) (Lysine N-methyltransferase 6)
Gene: EZH2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.62	0.60	0.611

Property	Details
Experiments	26496610, 36517590
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 3256 Hs			1 746
+	Hs
		331740 KI67_HUMAN (1-3256): 0: 1046: 100.00		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		807738 MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		801094 KI67_HUMAN (1-3256): 0: 1046: 100.00		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		165645 KI67_HUMAN (1-3256): 0: 1046: 100.00		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71
+	Hs
		1080130 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		1080263 MUC4_HUMAN (409-3101): 1.78e-16: 89.4: 12.06		EZH2_HUMAN (1-746): 0: 862: 100.00
+	Hs
		820995 PRC2A_HUMAN (513-2601): 5.1e-21: 104: 7.93		EZH1_HUMAN (15-745): 0: 745: 63.48
+	Hs
		331812 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		1056940 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		NSD1_HUMAN (275-729): 6.24e-90: 311: 15.82
+	Hs
		1056971 MDC1_HUMAN (20-1865): 6.71e-101: 366: 9.14		SETD2_HUMAN (190-732): 2.07e-89: 310: 16.64
+	Hs
		331745 MAP1B_HUMAN (771-2622): 1.91e-90: 333: 9.59		NSD2_HUMAN (275-729): 1.99e-91: 314: 16.03
+	Hs
		1244240 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		NSD3_HUMAN (275-729): 9.41e-70: 251: 14.42
+	Hs
		975287 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54
+	Hs
		1244253 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		SET1B_HUMAN (619-732): 1.38e-18: 93.2: 40.52
+	Hs
		165700 BD1L1_HUMAN (98-2862): 2.37e-19: 99.1: 9.63		SET1A_HUMAN (611-732): 3.19e-18: 92: 38.71
+	Dm
		54311 A1Z9J3_DROME (1658-3189): 4.27e-17: 91.7: 13.96		SET1_DROME (611-732): 1.27e-18: 93.2: 38.71
+	Hs
		975294 TITIN_HUMAN (52-1221): 1.55e-13: 80: 7.85		KMT2A_HUMAN (606-733): 6.89e-19: 94.4: 39.54