HitPredict

Interactor 1: 5HT3A (P46098)
5-hydroxytryptamine receptor 3A (5-HT3-A) (5-HT3A) (5-hydroxytryptamine receptor 3) (5-HT-3) (5-HT3R) (Serotonin receptor 3A) (Serotonin-gated ion channel receptor)
Gene: HTR3A

Interactor 2: LRC8E (Q6NSJ5)
Volume-regulated anion channel subunit LRRC8E (Leucine-rich repeat-containing protein 8E)
Gene: LRRC8E

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	0.60	0.628

Property	Details
Experiments	28514442, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 478 Hs			1 796
+	Hs
		802352 5HT3A_HUMAN (1-478): 2.75e-173: 497: 100.00		LRC8A_HUMAN (467-796): 1.41e-33: 140: 21.39
+	Hs
		802362 5HT3A_HUMAN (1-478): 2.75e-173: 497: 100.00		LRC8C_HUMAN (485-796): 3.55e-33: 139: 21.00
+	Hs
		802342 5HT3A_HUMAN (1-478): 2.75e-173: 497: 100.00		LRC8D_HUMAN (496-796): 1.31e-19: 96.2: 18.59
+	Hs
		506332 ACHB_HUMAN (31-470): 1.94e-148: 434: 23.62		LRC8A_HUMAN (467-796): 1.41e-33: 140: 21.39
+	Hs
		1219407 5HT3C_HUMAN (46-473): 3.65e-88: 278: 37.59		LRC8A_HUMAN (467-796): 1.41e-33: 140: 21.39
+	Hs
		798521 ACHA4_HUMAN (355-475): 1.85e-27: 117: 19.01		LRC8A_HUMAN (467-796): 1.41e-33: 140: 21.39
+	Hs
		798510 ACHA4_HUMAN (355-475): 1.85e-27: 117: 19.01		LRC8D_HUMAN (496-796): 1.31e-19: 96.2: 18.59
+	Hs
		798497 ACHA4_HUMAN (355-475): 1.85e-27: 117: 19.01		LRC8E_HUMAN (558-796): 1.93e-14: 79.6: 22.79