HitPredict

Interactor 1: ATRX (P46100)
Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)
Gene: ATRX

Interactor 2: H4 (P62805)
Histone H4
Gene: H4C1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.83	1.00	0.915

Property	Details
Experiments	28514442, 30804502, 33961781, 34349018, 23329831
Identification Methods	affinity chromatography technology, cross-linking study, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	CENP-T_C~Helicase_C, CENP-T_C~SNF2-rel_dom
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0006334 - nucleosome assembly
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 2492 Hs			1 103
+	Hs
		918003 HELLS_HUMAN (1364-2245): 8.17e-147: 482: 19.32		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		846914 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356551 IRC5_YEAST (1372-2300): 3.74e-147: 483: 20.62		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sp
		194289 FFT3_SCHPO (1560-2203): 2.47e-136: 454: 20.49		H4_SCHPO (18-103): 4.87e-42: 135: 89.54
+	Hs
		917261 HLTF_HUMAN (1358-2210): 3.39e-129: 436: 16.05		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356309 RAD16_YEAST (1379-2209): 3.36e-132: 438: 19.08		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Sc
		356310 FUN30_YEAST (1011-2227): 1.18e-125: 429: 18.00		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		918062 CHD7_HUMAN (1887-2476): 8.37e-73: 274: 15.08		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		229352 SMCA5_HUMAN (2009-2294): 1.7e-71: 264: 28.28		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917476 SRCAP_HUMAN (2007-2388): 3.12e-69: 262: 22.54		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917635 CHD6_HUMAN (1887-2468): 7.76e-69: 261: 15.31		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		918125 INO80_HUMAN (1919-2232): 2.04e-65: 249: 23.29		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356248 SNF2_YEAST (2008-2308): 2.25e-69: 262: 27.87		H4_YEAST (18-103): 6.13e-41: 132: 90.70
+	Hs
		917147 ERCC6_HUMAN (1559-1852): 9.81e-18: 92.8: 27.45		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Dm
		950383 ISWI_DROME (1587-1887): 4.52e-13: 77.4: 28.34		H4_DROME (1-103): 4.51e-48: 150: 99.03
+	Hs
		917182 CHD3_HUMAN (33-376): 3.04e-12: 75: 11.08		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Hs
		917277 CHD4_HUMAN (167-398): 6.48e-11: 70.4: 13.60		H4_HUMAN (1-103): 1.38e-48: 151: 100.00
+	Sc
		356774 ISW2_YEAST (1559-1890): 1.07e-13: 79.3: 28.31		H4_YEAST (18-103): 6.13e-41: 132: 90.70