HitPredict

Interactor 1: ATRX (P46100)
Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)
Gene: ATRX

Interactor 2: H31 (P68431)
Histone H3.1 (Histone H3/a) (Histone H3/b) (Histone H3/c) (Histone H3/d) (Histone H3/f) (Histone H3/h) (Histone H3/i) (Histone H3/j) (Histone H3/k) (Histone H3/l)
Gene: H3C1

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	1.00	0.909

Property	Details
Experiments	29568061, 34079125, 33961781, 36089195, 21421568
Identification Methods	proximity labelling technology, affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006325 - chromatin organization GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2492 Hs			1 136
+	Hs
		802423 ATRX_HUMAN (1-2492): 0: 1066: 100.00		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		802449 ATRX_HUMAN (1-2492): 0: 1066: 100.00		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Hs
		802404 ATRX_HUMAN (1-2492): 0: 1066: 100.00		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Mm
		952750 ATRX_MOUSE (1-2492): 0: 1017: 80.23		H33_MOUSE (1-136): 2.73e-61: 186: 96.32
+	Hs
		935281 HELLS_HUMAN (1364-2245): 8.17e-147: 482: 19.32		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952651 HELLS_HUMAN (1364-2245): 8.17e-147: 482: 19.32		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		846921 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		846989 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H31T_HUMAN (1-136): 1.27e-61: 187: 97.06
+	Hs
		846925 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Hs
		847003 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H32_HUMAN (1-136): 6.5e-61: 185: 99.27
+	Sp
		194291 FFT3_SCHPO (1560-2203): 2.47e-136: 454: 20.49		H31_SCHPO (1-136): 3.54e-59: 181: 91.91
+	Hs
		828391 HELLS_HUMAN (1364-2245): 8.17e-147: 482: 19.32		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		934759 HLTF_HUMAN (1358-2210): 3.39e-129: 436: 16.05		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952334 HLTF_HUMAN (1358-2210): 3.39e-129: 436: 16.05		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Sc
		679871 FUN30_YEAST (1011-2227): 1.18e-125: 429: 18.00		H3_YEAST (1-136): 1.16e-55: 172: 88.97
+	Hs
		828225 HLTF_HUMAN (1358-2210): 3.39e-129: 436: 16.05		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00
+	Hs
		935324 CHD7_HUMAN (1887-2476): 8.37e-73: 274: 15.08		H31_HUMAN (1-136): 2.8e-62: 188: 100.00
+	Hs
		952670 CHD7_HUMAN (1887-2476): 8.37e-73: 274: 15.08		H33_HUMAN (1-136): 2.73e-61: 186: 96.32
+	Mm
		935460 SMCA5_MOUSE (2009-2294): 1.18e-71: 265: 28.28		H31_MOUSE (1-136): 2.8e-62: 188: 100.00
+	Hs
		828410 CHD7_HUMAN (1887-2476): 8.37e-73: 274: 15.08		CENPA_HUMAN (9-133): 5.62e-45: 145: 50.00