HitPredict

Interactor 1: ATRX (P46100)
Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)
Gene: ATRX

Interactor 2: H33 (P84243)
Histone H3.3
Gene: H3-3A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	1.00	0.974

Property	Details
Experiments	29937341, 20110566, 25538301, 24981860, 33961781, 36089195, 20651253, 20504901, 24530302, 20211137
Identification Methods	affinity chromatography technology, x-ray crystallography, pull down, proximity labelling technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association, direct interaction

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0000781 - chromosome, telomeric region GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly GO:0031509 - subtelomeric heterochromatin formation and 1 others more... GO:0035264 - multicellular organism growth
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2492 Hs			1 136
+	Hs
		802419 ATRX_HUMAN (1-2492): 0: 1066: 100.00		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		802449 ATRX_HUMAN (1-2492): 0: 1066: 100.00		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Hs
		802404 ATRX_HUMAN (1-2492): 0: 1066: 100.00		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Mm
		952750 ATRX_MOUSE (1-2492): 0: 1017: 80.23		H33_MOUSE (1-136): 1.12e-59: 182: 100.00
+	Hs
		935281 HELLS_HUMAN (1364-2245): 8.17e-147: 482: 19.32		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952651 HELLS_HUMAN (1364-2245): 8.17e-147: 482: 19.32		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		846921 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		846925 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Hs
		846989 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H31T_HUMAN (1-136): 2.58e-59: 181: 93.38
+	Hs
		847003 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H32_HUMAN (1-136): 5.32e-59: 180: 97.06
+	Sp
		194291 FFT3_SCHPO (1560-2203): 2.47e-136: 454: 20.49		H31_SCHPO (1-136): 1.12e-57: 177: 91.91
+	Hs
		828391 HELLS_HUMAN (1364-2245): 8.17e-147: 482: 19.32		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		934759 HLTF_HUMAN (1358-2210): 3.39e-129: 436: 16.05		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952334 HLTF_HUMAN (1358-2210): 3.39e-129: 436: 16.05		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Sc
		679871 FUN30_YEAST (1011-2227): 1.18e-125: 429: 18.00		H3_YEAST (1-136): 3.62e-54: 168: 90.44
+	Hs
		828225 HLTF_HUMAN (1358-2210): 3.39e-129: 436: 16.05		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76
+	Hs
		935324 CHD7_HUMAN (1887-2476): 8.37e-73: 274: 15.08		H31_HUMAN (1-136): 3.08e-60: 183: 96.32
+	Hs
		952670 CHD7_HUMAN (1887-2476): 8.37e-73: 274: 15.08		H33_HUMAN (1-136): 1.12e-59: 182: 100.00
+	Mm
		935460 SMCA5_MOUSE (2009-2294): 1.18e-71: 265: 28.28		H31_MOUSE (1-136): 3.08e-60: 183: 96.32
+	Hs
		828410 CHD7_HUMAN (1887-2476): 8.37e-73: 274: 15.08		CENPA_HUMAN (9-133): 2.42e-45: 146: 50.76