HitPredict

Interactor 1: ATRX (P46100)
Transcriptional regulator ATRX (EC 3.6.4.12) (ATP-dependent helicase ATRX) (X-linked helicase II) (X-linked nuclear protein) (XNP) (Znf-HX)
Gene: ATRX

Interactor 2: H2B2E (Q16778)
Histone H2B type 2-E (H2B-clustered histone 21) (Histone H2B-GL105) (Histone H2B.q) (H2B/q)
Gene: H2BC21

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.62	1.00	0.789

Property	Details
Experiments	35271311, 23329831
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Histone~SNF2-rel_dom
Common GO terms	GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006334 - nucleosome assembly
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2492 Hs			1 126
+	Hs
		802416 ATRX_HUMAN (1-2492): 0: 1066: 100.00		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		802472 ATRX_HUMAN (1-2492): 0: 1066: 100.00		H2B1H_HUMAN (1-126): 6.27e-54: 166: 98.41
+	Hs
		241471 ATRX_HUMAN (1-2492): 0: 1066: 100.00		H2B1K_HUMAN (1-126): 1.56e-53: 165: 98.41
+	Hs
		802490 ATRX_HUMAN (1-2492): 0: 1066: 100.00		H2B1L_HUMAN (1-126): 2.49e-52: 162: 97.62
+	Hs
		918719 HELLS_HUMAN (1364-2245): 8.17e-147: 482: 19.32		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		846915 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		846990 SMCA4_HUMAN (1139-2410): 1.5e-134: 467: 12.88		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		1055124 HLTF_HUMAN (1358-2210): 3.39e-129: 436: 16.05		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		707628 HLTF_HUMAN (1358-2210): 3.39e-129: 436: 16.05		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Sp
		194285 FFT3_SCHPO (1560-2203): 2.47e-136: 454: 20.49		H2B1_SCHPO (4-125): 1.24e-45: 145: 70.49
+	Hs
		1055148 HLTF_HUMAN (1358-2210): 3.39e-129: 436: 16.05		H2B1A_HUMAN (1-126): 3.43e-46: 147: 85.04
+	Sc
		355819 RAD16_YEAST (1379-2209): 3.36e-132: 438: 19.08		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355386 RAD16_YEAST (1379-2209): 3.36e-132: 438: 19.08		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Sc
		355821 FUN30_YEAST (1011-2227): 1.18e-125: 429: 18.00		H2B2_YEAST (3-125): 4.73e-37: 124: 71.55
+	Sc
		355388 FUN30_YEAST (1011-2227): 1.18e-125: 429: 18.00		H2B1_YEAST (3-125): 1.81e-36: 122: 71.55
+	Hs
		1087449 CHD7_HUMAN (1887-2476): 8.37e-73: 274: 15.08		H2B2E_HUMAN (1-126): 6.69e-54: 166: 100.00
+	Hs
		918744 CHD7_HUMAN (1887-2476): 8.37e-73: 274: 15.08		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		707773 CHD7_HUMAN (1887-2476): 8.37e-73: 274: 15.08		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41
+	Hs
		229353 SMCA5_HUMAN (2009-2294): 1.7e-71: 264: 28.28		H2B1C_HUMAN (1-126): 1.18e-53: 166: 99.21
+	Hs
		229321 SMCA5_HUMAN (2009-2294): 1.7e-71: 264: 28.28		H2B1B_HUMAN (1-126): 1.74e-53: 165: 98.41