HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: PAXI (P49023)
Paxillin
Gene: PXN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.82	0.60	0.704

Property	Details
Experiments	10085298, 12198159, 15700267, 26656091, 12799422
Identification Methods	pull down, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0016477 - cell migration
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 591
+	Rn
		1144373 CRK_RAT (1-304): 7.32e-68: 215: 99.67		PAXI_RAT (12-591): 4.09e-126: 384: 81.77
+	Gg
		823525 CRK_CHICK (1-304): 1.96e-64: 206: 84.26		PAXI_CHICK (1-591): 3.03e-128: 389: 83.11
+	Rn
		1137277 CRKL_RAT (2-302): 9.86e-57: 186: 47.42		PAXI_RAT (12-591): 4.09e-126: 384: 81.77
+	Mm
		1144841 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		PAXI_MOUSE (12-591): 2.7e-114: 354: 93.62
+	Hs
		802806 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Mm
		815096 CRKL_MOUSE (2-302): 6.92e-57: 187: 47.10		PAXI_MOUSE (12-591): 2.7e-114: 354: 93.62
+	Hs
		823423 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		823365 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		209008 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		557639 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		PAXI_HUMAN (12-591): 3.81e-117: 361: 100.00
+	Hs
		802757 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		ZKSC7_HUMAN (76-414): 2.77e-48: 181: 8.91
+	Hs
		275170 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		ZN250_HUMAN (70-463): 7.31e-70: 237: 13.07
+	Hs
		562668 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		ZKSC7_HUMAN (76-414): 2.77e-48: 181: 8.91
+	Hs
		300996 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ABLM3_HUMAN (416-590): 1.41e-40: 158: 29.03
+	Hs
		924889 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		PDLI7_HUMAN (473-590): 2.88e-34: 137: 33.90
+	Hs
		150515 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32
+	Hs
		150611 Q96D37_HUMAN (11-189): 5.17e-47: 170: 28.21		ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32
+	Hs
		209005 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		LIMS1_HUMAN (346-529): 1.14e-43: 160: 32.97
+	Mm
		250825 PLCG2_MOUSE (11-301): 1.34e-25: 108: 16.40		FHL2_MOUSE (329-467): 3.02e-25: 107: 26.57
+	Hs
		150552 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ABLM1_HUMAN (512-590): 6.08e-10: 64.4: 25.32