HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: DYN2 (P50570)
Dynamin-2 (EC 3.6.5.5) (Dynamin 2) (Dynamin II)
Gene: DNM2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~SH3_1
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0017124 - SH3 domain binding and 1 others more... GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 870
+	Hs
		840739 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		275181 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		983387 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Hs
		1167839 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Mm
		760474 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Hs
		840663 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		840686 GRAP_HUMAN (135-294): 3.79e-21: 91.4: 16.67		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Mm
		760488 ITSN1_MOUSE (143-302): 6.55e-13: 71.4: 10.98		DYN2_MOUSE (1-870): 0: 1057: 98.16
+	Hs
		840840 ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Hs
		840878 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		DYN2_HUMAN (1-870): 0: 1057: 100.00
+	Mm
		760450 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DYN1_MOUSE (1-844): 0: 1003: 79.23
+	Hs
		924499 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DYN1_HUMAN (1-846): 0: 1002: 79.04
+	Rn
		599402 GRB2_RAT (135-297): 2.78e-25: 102: 15.67		DYN1_RAT (1-846): 0: 994: 78.57
+	Hs
		924956 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DYN3_HUMAN (1-870): 0: 994: 78.41
+	Mm
		1141147 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DYN3_MOUSE (1-870): 0: 992: 77.90
+	Mm
		760469 ITSN1_MOUSE (143-302): 6.55e-13: 71.4: 10.98		DYN1_MOUSE (1-844): 0: 1003: 79.23
+	Rn
		599413 ITSN1_RAT (185-302): 1.12e-11: 67.5: 14.17		DYN1_RAT (1-846): 0: 994: 78.57
+	Dm
		649302 GRAP_DROME (135-293): 4.02e-23: 96.4: 16.43		DYN_DROME (6-842): 0: 928: 66.23
+	Ce
		666206 SEM5_CAEEL (135-291): 6.58e-25: 101: 14.83		DYN1_CAEEL (3-823): 0: 899: 61.86
+	Ce
		760500 VAV_CAEEL (13-194): 4.87e-22: 98.4: 23.94		DYN1_CAEEL (3-823): 0: 899: 61.86