HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: K22O (Q01546)
Keratin, type II cytoskeletal 2 oral (Cytokeratin-2P) (CK-2P) (K2P) (Keratin-76) (K76) (Type-II keratin Kb9)
Gene: KRT76

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	19380743
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 638
+	Hs
		409026 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59
+	Hs
		409124 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59
+	Hs
		802658 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C78_HUMAN (101-556): 3.14e-131: 397: 55.48
+	Hs
		409046 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		K2C8_HUMAN (155-533): 2.09e-168: 491: 63.59
+	Hs
		380578 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C1_HUMAN (148-514): 4.75e-112: 351: 68.94
+	Hs
		802644 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C1B_HUMAN (53-514): 2.59e-111: 348: 60.82
+	Hs
		444533 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		K2C7_HUMAN (66-510): 2.56e-144: 429: 58.20
+	Hs
		802647 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C73_HUMAN (64-499): 2.7e-88: 286: 61.09
+	Hs
		531539 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C5_HUMAN (1-499): 2.07e-83: 275: 63.64
+	Hs
		802619 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C79_HUMAN (73-508): 4.13e-81: 267: 64.16
+	Hs
		380448 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C6B_HUMAN (2-515): 5.13e-80: 265: 62.02
+	Hs
		359471 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C6A_HUMAN (2-515): 1.3e-76: 256: 62.60
+	Hs
		517743 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		K2C3_HUMAN (1-500): 1.54e-69: 239: 77.99
+	Hs
		380590 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		K2C1_HUMAN (148-514): 4.75e-112: 351: 68.94
+	Hs
		213936 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		KRT86_HUMAN (76-511): 4.02e-93: 297: 49.54
+	Hs
		531551 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		K2C5_HUMAN (1-499): 2.07e-83: 275: 63.64
+	Hs
		359480 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		K2C6A_HUMAN (2-515): 1.3e-76: 256: 62.60
+	Mm
		1141145 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		Q8BIS2_MOUSE (39-499): 6.9e-66: 227: 57.92
+	Hs
		280786 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		KRT36_HUMAN (91-496): 5.78e-67: 228: 25.12
+	Mm
		1060206 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		Q148Q7_MOUSE (39-499): 1.13e-65: 226: 57.92