HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: TCOF (Q13428)
Treacle protein (Treacher Collins syndrome protein)
Gene: TCOF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	35044719
Identification Methods	unspecified method, phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0097110 - scaffold protein binding
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 1488
+	Hs
		807680 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		MAP1B_HUMAN (41-1111): 4.34e-44: 178: 10.34
+	Hs
		1056926 SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22		MDC1_HUMAN (238-1377): 7.73e-52: 203: 12.82
+	Ce
		136804 VAV_CAEEL (13-194): 4.87e-22: 98.4: 23.94		UNC89_CAEEL (813-1485): 4.08e-31: 136: 16.59
+	Hs
		924760 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		PRG4_HUMAN (57-777): 8.7e-26: 118: 12.34
+	Hs
		855816 VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74		TITIN_HUMAN (91-778): 3.15e-09: 64.2: 9.45
+	Hs
		554292 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		MUC1_HUMAN (180-968): 3.18e-10: 67.4: 14.83
+	Hs
		924473 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		MAP1A_HUMAN (34-656): 9.21e-10: 66.1: 10.05
+	Hs
		924484 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ANK2_HUMAN (195-1161): 9.81e-10: 65.9: 15.17
+	Hs
		203218 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		SYNJ1_HUMAN (999-1481): 6.17e-09: 63: 12.40
+	Hs
		557660 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		ANK2_HUMAN (195-1161): 9.81e-10: 65.9: 15.17
+	Hs
		203208 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		SYNJ1_HUMAN (999-1481): 6.17e-09: 63: 12.40
+	Hs
		203228 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		SYNJ1_HUMAN (999-1481): 6.17e-09: 63: 12.40
+	Hs
		203241 SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22		SYNJ1_HUMAN (999-1481): 6.17e-09: 63: 12.40