HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: ASPP2 (Q13625)
Apoptosis-stimulating of p53 protein 2 (Bcl2-binding protein) (Bbp) (Renal carcinoma antigen NY-REN-51) (Tumor suppressor p53-binding protein 2) (53BP2) (p53-binding protein 2) (p53BP2)
Gene: TP53BP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.57	1.00	0.757

Property	Details
Experiments	26871637, 17474147
Identification Methods	two hybrid, peptide array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH2~SH3_1, Ank_2~SH3_1, SH3_1~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0017124 - SH3 domain binding
Homologous interactions	15

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 1128
+	Hs
		924553 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		802572 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90
+	Hs
		1043723 SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22		ASPP2_HUMAN (1-1128): 0: 599: 100.00
+	Hs
		985571 SH3K1_HUMAN (114-192): 4.08e-10: 62.5: 22.22		Q05BL1_HUMAN (90-1128): 2.47e-152: 484: 99.90
+	Hs
		161327 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89
+	Rn
		1137278 CRKL_RAT (2-302): 9.86e-57: 186: 47.42		KDIS_RAT (779-1029): 1.14e-21: 104: 11.86
+	Hs
		161301 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89
+	Hs
		208966 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		PSD10_HUMAN (988-1128): 3e-43: 159: 16.77
+	Hs
		1078843 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		ANR54_HUMAN (902-1045): 1.27e-39: 151: 31.97
+	Ce
		136804 VAV_CAEEL (13-194): 4.87e-22: 98.4: 23.94		UNC89_CAEEL (417-929): 1.19e-21: 104: 12.78
+	Hs
		924794 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		EHMT2_HUMAN (687-995): 4.44e-17: 89.1: 10.35
+	Hs
		161352 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		MYPT1_HUMAN (957-1059): 1.81e-16: 87.2: 36.89
+	Hs
		1349277 ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86		DAPLE_HUMAN (33-349): 6.45e-16: 85.6: 16.36
+	Hs
		557772 NCK1_HUMAN (2-100): 1.55e-10: 63.3: 18.00		EHMT2_HUMAN (687-995): 4.44e-17: 89.1: 10.35
+	Ce
		105099 Q9U2T9_CAEEL (182-300): 9.9e-11: 64.7: 13.22		G5ECD7_CAEEL (931-1059): 2.42e-13: 76.8: 29.41