HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: LASP1 (Q14847)
LIM and SH3 domain protein 1 (LASP-1) (Metastatic lymph node gene 50 protein) (MLN 50)
Gene: LASP1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	1.00	0.767

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	SH3_2~SH3_9
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 261
+	Hs
		548630 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77
+	Hs
		924563 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		ARHG7_HUMAN (43-261): 1.37e-25: 107: 14.16
+	Hs
		562646 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Rn
		499156 PLCG1_RAT (8-302): 1.46e-26: 111: 15.72		PLCG1_RAT (14-261): 1.2e-21: 96.1: 16.94
+	Hs
		562619 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77
+	Dm
		993202 GRAP_DROME (135-293): 4.02e-23: 96.4: 16.43		Q9VDF4_DROME (102-261): 1.79e-26: 109: 24.59
+	Hs
		924570 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Hs
		562638 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		PLCG2_HUMAN (15-261): 2.82e-22: 98: 13.77
+	Rn
		499159 GRB2_RAT (135-297): 2.78e-25: 102: 15.67		PLCG1_RAT (14-261): 1.2e-21: 96.1: 16.94
+	Xl
		60960 GRB2A_XENLA (135-297): 8.98e-17: 79.5: 11.84		A5LHG3_XENLA (14-261): 4.67e-24: 103: 18.55
+	Hs
		924617 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		SH319_HUMAN (189-261): 2.12e-13: 71.4: 35.62
+	Hs
		209051 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		ARHG7_HUMAN (43-261): 1.37e-25: 107: 14.16
+	Hs
		209189 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		BAIP2_HUMAN (19-261): 1.26e-24: 104: 15.75
+	Hs
		1307421 ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86		SH3G1_HUMAN (48-261): 6.99e-24: 100: 18.81
+	Hs
		1052363 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		SRC8_HUMAN (38-260): 4.28e-23: 99: 17.62
+	Hs
		1307444 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		SH3G2_HUMAN (47-261): 5.88e-23: 98: 18.14
+	Rn
		71363 B2RZ33_RAT (2-100): 1.35e-10: 63.3: 18.00		SRC8_RAT (36-260): 3.53e-23: 99: 22.55
+	Mm
		1143925 SH3K1_MOUSE (114-186): 2.23e-10: 63.3: 21.33		SH3G2_MOUSE (47-261): 9.83e-23: 97.2: 17.21
+	Mm
		1208602 SH3K1_MOUSE (114-186): 2.23e-10: 63.3: 21.33		PLCG2_MOUSE (17-261): 7.01e-22: 96.9: 13.88
+	Hs
		209154 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		SRBS1_HUMAN (149-259): 7.54e-13: 69.9: 31.30