HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: DOK3 (Q7L591)
Docking protein 3 (Downstream of tyrosine kinase 3)
Gene: DOK3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.594

Property	Details
Experiments	25814554, unassigned1126
Identification Methods	two hybrid, two hybrid array, validated two hybrid
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 496
+	Hs
		802714 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOK1_HUMAN (60-491): 1.13e-123: 371: 29.92
+	Hs
		802892 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOK1_HUMAN (60-491): 1.13e-123: 371: 29.92
+	Mm
		1141171 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DOK3_MOUSE (57-496): 1.2e-152: 444: 77.70
+	Hs
		548746 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		DOK1_HUMAN (60-491): 1.13e-123: 371: 29.92
+	Hs
		151733 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		IRS4_HUMAN (65-427): 3e-89: 298: 15.90
+	Hs
		235053 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOK2_HUMAN (61-455): 2.1e-95: 296: 34.04
+	Mm
		724603 CRK_MOUSE (1-304): 5.53e-68: 215: 99.67		IRS1_MOUSE (65-494): 2.12e-87: 293: 15.32
+	Hs
		151734 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		IRS4_HUMAN (65-427): 3e-89: 298: 15.90
+	Hs
		235054 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOK2_HUMAN (61-455): 2.1e-95: 296: 34.04
+	Hs
		581044 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		DOK1_HUMAN (60-491): 1.13e-123: 371: 29.92
+	Mm
		956520 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DOK1_MOUSE (60-491): 4.19e-125: 375: 30.19
+	Hs
		802675 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		FRS2_HUMAN (198-491): 2.68e-66: 224: 19.81
+	Hs
		151706 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		IRS4_HUMAN (65-427): 3e-89: 298: 15.90
+	Hs
		235042 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		DOK2_HUMAN (61-455): 2.1e-95: 296: 34.04
+	Hs
		562631 PLCG2_HUMAN (1-301): 1.03e-25: 109: 15.89		IRS1_HUMAN (65-494): 2.85e-88: 296: 15.58
+	Mm
		724599 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		IRS1_MOUSE (65-494): 2.12e-87: 293: 15.32
+	Hs
		581086 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		IRS2_HUMAN (65-452): 3.56e-75: 259: 13.38
+	Mm
		946348 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		IRS2_MOUSE (65-452): 6.66e-78: 267: 13.48
+	Rn
		88884 GRB2_RAT (135-297): 2.78e-25: 102: 15.67		D4A244_RAT (198-490): 3.9e-64: 218: 19.88
+	Mm
		1141149 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		FRS2_MOUSE (198-490): 2.26e-62: 213: 19.57