HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: FRS2 (Q8WU20)
Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)
Gene: FRS2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	10092678
Identification Methods	pull down
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 508
+	Hs
		924725 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		FRS2_HUMAN (1-508): 0: 590: 100.00
+	Mm
		1141149 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		FRS2_MOUSE (1-508): 0: 577: 95.87
+	Rn
		88884 GRB2_RAT (135-297): 2.78e-25: 102: 15.67		D4A244_RAT (1-508): 0: 575: 95.47
+	Hs
		207394 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		FRS3_HUMAN (1-508): 8.04e-165: 477: 47.51
+	Hs
		802714 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOK1_HUMAN (14-333): 1.42e-84: 271: 19.36
+	Hs
		802892 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOK1_HUMAN (14-333): 1.42e-84: 271: 19.36
+	Hs
		548746 VAV_HUMAN (11-189): 6.6e-47: 170: 28.21		DOK1_HUMAN (14-333): 1.42e-84: 271: 19.36
+	Hs
		235053 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOK2_HUMAN (20-293): 4.2e-58: 199: 20.42
+	Hs
		802639 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		DOK3_HUMAN (20-286): 7.1e-51: 182: 20.79
+	Hs
		235054 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		DOK2_HUMAN (20-293): 4.2e-58: 199: 20.42
+	Hs
		581044 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		DOK1_HUMAN (14-333): 1.42e-84: 271: 19.36
+	Mm
		956520 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DOK1_MOUSE (14-332): 4.77e-85: 272: 18.82
+	Hs
		924816 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DOK1_HUMAN (14-333): 1.42e-84: 271: 19.36
+	Mm
		223011 NCK2_MOUSE (59-195): 2.76e-11: 65.3: 20.55		DOK1_MOUSE (14-332): 4.77e-85: 272: 18.82
+	Hs
		209149 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		DOK1_HUMAN (14-333): 1.42e-84: 271: 19.36
+	Hs
		235042 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		DOK2_HUMAN (20-293): 4.2e-58: 199: 20.42
+	Mm
		1141171 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DOK3_MOUSE (19-289): 1.53e-55: 194: 19.79
+	Hs
		924665 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DOK3_HUMAN (20-286): 7.1e-51: 182: 20.79
+	Mm
		223005 NCK2_MOUSE (59-195): 2.76e-11: 65.3: 20.55		DOK2_MOUSE (20-293): 2.39e-60: 206: 20.85
+	Hs
		208960 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		DOK2_HUMAN (20-293): 4.2e-58: 199: 20.42