HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: M4K1 (Q92918)
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)
Gene: MAP4K1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.717

Property	Details
Experiments	32640226, 9891069, 9788432, 11279207, 17474147
Identification Methods	affinity chromatography technology, pull down, peptide array
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0008283 - cell population proliferation GO:0016020 - membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 833
+	Hs
		802883 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		802792 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		M4K5_HUMAN (7-820): 0: 864: 44.15
+	Hs
		802924 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		M4K5_HUMAN (7-820): 0: 864: 44.15
+	Hs
		802868 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		M4K3_HUMAN (7-820): 0: 863: 38.76
+	Hs
		275218 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		581035 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		924745 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		209135 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		M4K1_HUMAN (1-833): 0: 901: 100.00
+	Hs
		924984 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		M4K5_HUMAN (7-820): 0: 864: 44.15
+	Hs
		924683 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		M4K3_HUMAN (7-820): 0: 863: 38.76
+	Hs
		1217590 ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86		M4K3_HUMAN (7-820): 0: 863: 38.76
+	Mm
		292682 GRAP2_MOUSE (18-192): 6.73e-14: 72.9: 19.79		M4K1_MOUSE (1-810): 0: 815: 83.80
+	Hs
		580944 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Hs
		282275 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		CDKL5_HUMAN (12-589): 4.98e-125: 400: 18.62
+	Hs
		855832 VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74		STK24_HUMAN (9-295): 4.54e-116: 361: 42.36
+	Hs
		682092 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		AKT1_HUMAN (1-337): 6.85e-129: 396: 23.12
+	Dm
		993188 GRAP_DROME (135-293): 4.02e-23: 96.4: 16.43		Q7KV89_DROME (11-340): 1.95e-68: 248: 41.31
+	Hs
		924703 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		MINK1_HUMAN (11-296): 6.63e-61: 226: 43.58
+	Hs
		209186 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		TNIK_HUMAN (11-296): 3.35e-64: 236: 42.57
+	Hs
		209112 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		MINK1_HUMAN (11-296): 6.63e-61: 226: 43.58