HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: GRIP2 (Q9C0E4)
Glutamate receptor-interacting protein 2 (GRIP-2)
Gene: GRIP2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	17474147
Identification Methods	peptide array
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PDZ~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 1043
+	Hs
		924847 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		GRIP2_HUMAN (1-1043): 0: 590: 100.00
+	Hs
		280031 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		MPDZ_HUMAN (6-230): 5.76e-32: 137: 20.62
+	Dm
		1181705 CRK_DROME (5-302): 8.8e-52: 173: 43.14		SCRIB_DROME (323-1030): 1.64e-40: 165: 16.35
+	Hs
		802659 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		LNX2_HUMAN (4-128): 5.71e-17: 88.1: 18.75
+	Hs
		275214 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		LNX1_HUMAN (445-734): 8.17e-34: 141: 19.94
+	Hs
		924466 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		DLG4_HUMAN (612-1043): 6.44e-38: 154: 14.64
+	Mm
		1141133 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		DLG4_MOUSE (509-808): 1.72e-33: 140: 14.97
+	Hs
		924718 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		LNX1_HUMAN (445-734): 8.17e-34: 141: 19.94
+	Hs
		275210 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		LNX2_HUMAN (4-128): 5.71e-17: 88.1: 18.75
+	Hs
		209122 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		LNX1_HUMAN (445-734): 8.17e-34: 141: 19.94
+	Mm
		223014 NCK2_MOUSE (59-195): 2.76e-11: 65.3: 20.55		DLG4_MOUSE (509-808): 1.72e-33: 140: 14.97
+	Mm
		1143451 SH3K1_MOUSE (114-186): 2.23e-10: 63.3: 21.33		DLG4_MOUSE (509-808): 1.72e-33: 140: 14.97
+	Hs
		924701 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		LNX2_HUMAN (4-128): 5.71e-17: 88.1: 18.75