HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: GARE1 (Q9H706)
GRB2-associated and regulator of MAPK protein 1 (GRB2-associated and regulator of MAPK1)
Gene: GAREM1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.70	0.60	0.651

Property	Details
Experiments	25814554, 35044719, unassigned1126
Identification Methods	two hybrid, unspecified method, two hybrid array, validated two hybrid, phage display
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 304 Hs			1 876
+	Hs
		802904 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		GARE1_HUMAN (1-876): 0: 1707: 100.00
+	Hs
		275228 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		GARE1_HUMAN (1-876): 0: 1707: 100.00
+	Hs
		581056 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		GARE1_HUMAN (1-876): 0: 1707: 100.00
+	Hs
		924865 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		GARE1_HUMAN (1-876): 0: 1707: 100.00
+	Mm
		1112482 GRB2_MOUSE (135-297): 1.43e-25: 103: 15.67		GARE1_MOUSE (1-876): 0: 1682: 91.45
+	Hs
		1332845 ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86		GARE1_HUMAN (1-876): 0: 1707: 100.00
+	Hs
		209170 NCK2_HUMAN (2-100): 3.06e-11: 65.2: 18.00		GARE1_HUMAN (1-876): 0: 1707: 100.00
+	Hs
		924662 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		GARE2_HUMAN (432-876): 4.97e-46: 180: 35.53
+	Hs
		1176016 ITSN2_HUMAN (189-304): 5.82e-12: 68.3: 11.86		GARE2_HUMAN (432-876): 4.97e-46: 180: 35.53
+	Hs
		1078850 ITSN1_HUMAN (150-302): 3.02e-10: 63.3: 13.87		GARE2_HUMAN (432-876): 4.97e-46: 180: 35.53