HitPredict

Interactor 1: CRK (P46108)
Adapter molecule crk (Proto-oncogene c-Crk) (p38)
Gene: CRK

Interactor 2: M4K5 (Q9Y4K4)
Mitogen-activated protein kinase kinase kinase kinase 5 (EC 2.7.11.1) (Kinase homologous to SPS1/STE20) (KHS) (MAPK/ERK kinase kinase kinase 5) (MEK kinase kinase 5) (MEKKK 5)
Gene: MAP4K5

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.79	0.60	0.691

Property	Details
Experiments	10648385, 32640226, 19380743, 9788432
Identification Methods	affinity chromatography technology, pull down, tandem affinity purification, coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 304 Hs			1 846
+	Hs
		802924 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		M4K5_HUMAN (1-846): 0: 1037: 100.00
+	Hs
		924984 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		M4K5_HUMAN (1-846): 0: 1037: 100.00
+	Hs
		802868 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		M4K3_HUMAN (7-846): 0: 940: 64.55
+	Hs
		924683 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		M4K3_HUMAN (7-846): 0: 940: 64.55
+	Hs
		802687 CRK_HUMAN (1-304): 7.82e-68: 215: 100.00		M4K1_HUMAN (9-845): 0: 774: 44.52
+	Hs
		802883 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		M4K1_HUMAN (9-845): 0: 774: 44.52
+	Hs
		275218 GRAP2_HUMAN (1-296): 5.17e-33: 125: 17.17		M4K1_HUMAN (9-845): 0: 774: 44.52
+	Hs
		581035 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		M4K1_HUMAN (9-845): 0: 774: 44.52
+	Hs
		924745 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		M4K1_HUMAN (9-845): 0: 774: 44.52
+	Mm
		292682 GRAP2_MOUSE (18-192): 6.73e-14: 72.9: 19.79		M4K1_MOUSE (9-838): 0: 786: 44.31
+	Hs
		1039093 DNMBP_HUMAN (119-293): 5.7e-46: 168: 29.35		KCC2D_HUMAN (8-517): 1.77e-144: 437: 18.38
+	Hs
		924549 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		KCC2D_HUMAN (8-517): 1.77e-144: 437: 18.38
+	Hs
		581082 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		KCC2A_HUMAN (8-488): 3.27e-138: 420: 19.26
+	Hs
		580944 PLCG1_HUMAN (1-302): 7.99e-27: 112: 15.39		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		855832 VAV2_HUMAN (2-191): 3.44e-29: 119: 19.74		STK24_HUMAN (8-379): 1.48e-118: 368: 37.53
+	Hs
		682092 CD2AP_HUMAN (1-196): 4.74e-12: 68.3: 17.12		AKT1_HUMAN (12-346): 6.18e-125: 386: 22.38
+	Hs
		324759 CRKL_HUMAN (2-302): 4.5e-57: 187: 48.07		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51
+	Dm
		993188 GRAP_DROME (135-293): 4.02e-23: 96.4: 16.43		Q7KV89_DROME (14-320): 8.51e-77: 272: 42.46
+	Hs
		924703 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		MINK1_HUMAN (3-295): 3.13e-70: 254: 45.28
+	Hs
		324782 GRB2_HUMAN (135-297): 2.78e-25: 102: 15.67		M4K4_HUMAN (2-295): 4.04e-64: 236: 43.51