HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: SOS1 (Q07889)
Son of sevenless homolog 1 (SOS-1)
Gene: SOS1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.77	1.00	0.881

Property	Details
Experiments	32203420, 26496610, 33961781, unassigned2213
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	PH~SH3_1, RhoGEF~SH3_1
Common GO terms	GO:0005829 - cytosol GO:0007165 - signal transduction GO:0007265 - Ras protein signal transduction GO:0008543 - fibroblast growth factor receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 1333
+	Hs
		103875 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		G5E9C8_HUMAN (1-1333): 0: 972: 98.28
+	Mm
		815092 CRKL_MOUSE (1-303): 2.79e-72: 227: 96.70		SOS1_MOUSE (1-1333): 0: 957: 96.47
+	Hs
		802575 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		580987 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		SOS1_HUMAN (1-1333): 0: 991: 100.00
+	Hs
		802827 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Mm
		1143290 PLCG1_MOUSE (5-224): 3.19e-29: 119: 16.95		SOS1_MOUSE (1-1333): 0: 957: 96.47
+	Hs
		802576 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		275188 GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Hs
		580988 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		SOS2_HUMAN (1-1332): 0: 855: 68.03
+	Mm
		970656 PLCG2_MOUSE (5-192): 3.94e-27: 113: 18.72		SOS2_MOUSE (1-1332): 0: 851: 67.66
+	Hs
		802840 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Hs
		802594 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		RPGF1_HUMAN (571-1032): 8.27e-91: 320: 23.63
+	Mm
		1144842 CRK_MOUSE (3-302): 5.71e-54: 180: 55.21		Q91ZZ2_MOUSE (593-1032): 1.46e-88: 314: 24.21
+	Mm
		815095 CRKL_MOUSE (1-303): 2.79e-72: 227: 96.70		Q8C5V7_MOUSE (544-1004): 5.17e-76: 267: 22.68
+	Hs
		548657 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Mm
		1144839 CRK_MOUSE (3-302): 5.71e-54: 180: 55.21		Q8C5V7_MOUSE (544-1004): 5.17e-76: 267: 22.68
+	Hs
		581033 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		RPGF5_HUMAN (522-1018): 7.32e-85: 291: 16.12
+	Hs
		548634 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		VAV_HUMAN (134-691): 1.71e-76: 274: 14.41
+	Dm
		284706 CRK_DROME (5-302): 5.43e-48: 163: 42.05		C3G_DROME (776-1024): 1.5e-24: 114: 29.92
+	Mm
		1143293 PLCG1_MOUSE (5-224): 3.19e-29: 119: 16.95		RGPS2_MOUSE (774-1023): 3.11e-23: 108: 27.17