HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: ACK1 (Q07912)
Activated CDC42 kinase 1 (ACK-1) (EC 2.7.10.2) (EC 2.7.11.1) (Tyrosine kinase non-receptor protein 2)
Gene: TNK2

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	28739485
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PK_Tyr_Ser-Thr~SH2, PK_Tyr_Ser-Thr~SH3_1, SH3_2~SH3_9
Common GO terms	GO:0005829 - cytosol
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 1038
+	Hs
		802577 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ACK1_HUMAN (1-1038): 0: 805: 100.00
+	Mm
		337621 CRKL_MOUSE (1-303): 2.79e-72: 227: 96.70		ABL1_MOUSE (1-955): 1.72e-152: 484: 20.27
+	Hs
		337389 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Mm
		337631 CRK_MOUSE (3-302): 5.71e-54: 180: 55.21		ABL1_MOUSE (1-955): 1.72e-152: 484: 20.27
+	Hs
		802847 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17
+	Hs
		789044 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68
+	Hs
		337388 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ABL1_HUMAN (1-955): 4.84e-144: 462: 19.03
+	Hs
		802810 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		EPHA4_HUMAN (84-486): 5.91e-125: 407: 23.98
+	Hs
		433280 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		YES_HUMAN (1-400): 1.3e-128: 403: 29.93
+	Hs
		69205 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		A9UF07_HUMAN (1-955): 2.36e-134: 447: 19.03
+	Hs
		802571 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		FAK1_HUMAN (6-692): 3.3e-131: 425: 21.01
+	Hs
		802607 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ERBB4_HUMAN (84-754): 3.34e-128: 423: 24.17
+	Hs
		789043 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		ABL2_HUMAN (1-845): 1.9e-126: 415: 19.68
+	Hs
		665560 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		EPHB2_HUMAN (10-539): 5.4e-127: 414: 21.60
+	Hs
		522848 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		SRC_HUMAN (1-400): 3.99e-127: 399: 31.42
+	Mm
		1144837 CRK_MOUSE (3-302): 5.71e-54: 180: 55.21		Q8BRB1_MOUSE (109-456): 3.15e-117: 386: 32.40
+	Hs
		665378 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		EPHA3_HUMAN (109-456): 3.37e-117: 386: 30.34
+	Hs
		338102 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Hs
		338101 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		EGFR_HUMAN (105-387): 2.98e-55: 211: 39.58
+	Hs
		789019 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		TXK_HUMAN (121-381): 1.27e-50: 189: 40.46