HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: DOCK1 (Q14185)
Dedicator of cytokinesis protein 1 (180 kDa protein downstream of CRK) (DOCK180)
Gene: DOCK1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.65	1.00	0.811

Property	Details
Experiments	26496610, 33961781
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	SH2~SH3_1, SH3_1~SH3_1, DOCK_N~SH3_2, SH3_1~SH3_2
Common GO terms	GO:0005654 - nucleoplasm GO:0005829 - cytosol GO:0007165 - signal transduction GO:0016477 - cell migration GO:1900026 - positive regulation of substrate adhesion-dependent cell spreading
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 1865
+	Hs
		802596 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		557689 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		924565 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		DOCK1_HUMAN (1-1865): 0: 2184: 100.00
+	Hs
		802881 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		DOCK2_HUMAN (1-1805): 0: 1960: 59.80
+	Hs
		802906 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		DOCK5_HUMAN (1-1844): 0: 1934: 62.63
+	Hs
		802731 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		DOCK5_HUMAN (1-1844): 0: 1934: 62.63
+	Hs
		548738 VAV_HUMAN (214-293): 3.43e-15: 77.9: 30.86		DOCK2_HUMAN (1-1805): 0: 1960: 59.80
+	Hs
		802655 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Dm
		1362940 CRK_DROME (5-302): 5.43e-48: 163: 42.05		Q9VCH4_DROME (1-1822): 0: 1783: 38.87
+	Hs
		557736 NCK1_HUMAN (85-196): 4.12e-16: 79.8: 22.81		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		924695 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		DOCK3_HUMAN (4-1851): 0: 1771: 36.75
+	Hs
		924698 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		DOCK4_HUMAN (4-1855): 0: 1748: 36.35
+	Ce
		107035 CED2_CAEEL (1-298): 3.79e-38: 138: 27.10		G5EEN3_CAEEL (13-1699): 0: 1378: 28.64
+	Dm
		1228832 CRK_DROME (5-302): 5.43e-48: 163: 42.05		Q8MQW7_DROME (665-1822): 0: 1067: 38.49
+	Hs
		496517 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		496268 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		496239 PLCG2_HUMAN (5-188): 2.6e-27: 113: 19.10		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		496788 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		TAU_HUMAN (1502-1858): 1.32e-26: 120: 12.30
+	Hs
		1056926 SH3K1_HUMAN (219-297): 1.64e-15: 78.7: 24.69		MDC1_HUMAN (1604-1861): 7.61e-10: 66.7: 16.67
+	Hs
		924760 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		PRG4_HUMAN (1634-1856): 2.09e-09: 65.2: 13.39