HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: TENS2 (Q63HR2)
Tensin-2 (EC 3.1.3.48) (C1 domain-containing phosphatase and tensin homolog) (C1-TEN) (Tensin-like C1 domain-containing phosphatase)
Gene: TNS2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.75	0.80	0.778

Property	Details
Experiments	25814554, 28675297, 21988832, unassigned1126
Identification Methods	two hybrid, affinity chromatography technology, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	C1_1~SH2, SH2~SH2, SH2~SH3_1, SH2~SH3_2
Common GO terms	-
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 303 Hs			1 1409
+	Hs
		782795 CSK_HUMAN (129-180): 8.43e-11: 64.1: 43.40		TENS2_HUMAN (1-1409): 0: 748: 100.00
+	Hs
		924632 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		TENS2_HUMAN (1-1409): 0: 748: 100.00
+	Hs
		782797 CSK_HUMAN (129-180): 8.43e-11: 64.1: 43.40		TENS3_HUMAN (125-1409): 1.7e-168: 545: 33.49
+	Hs
		802812 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		PTEN_HUMAN (118-478): 6.4e-114: 365: 24.37
+	Rn
		222445 CSK_RAT (129-180): 8.43e-11: 64.1: 43.40		PTEN_RAT (118-478): 7.3e-114: 365: 24.37
+	Hs
		890585 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		PTEN_HUMAN (118-478): 6.4e-114: 365: 24.37
+	Hs
		802654 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		KMT2E_HUMAN (584-1277): 4.19e-10: 67: 10.45
+	Hs
		554292 GRB2_HUMAN (240-295): 1.72e-10: 61.8: 26.32		MUC1_HUMAN (747-1330): 8.52e-25: 114: 12.10
+	Hs
		782828 CSK_HUMAN (129-180): 8.43e-11: 64.1: 43.40		TENS1_HUMAN (427-1338): 2.81e-12: 74: 11.34