HitPredict

Interactor 1: CRKL (P46109)
Crk-like protein
Gene: CRKL

Interactor 2: BLNK (Q8WV28)
B-cell linker protein (B-cell adapter containing a SH2 domain protein) (B-cell adapter containing a Src homology 2 domain protein) (Cytoplasmic adapter protein) (Src homology 2 domain-containing leukocyte protein of 65 kDa) (SLP-65)
Gene: BLNK

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	11489945
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	SH2~SH2, SH2~SH3_1, SH2~SH3_2
Common GO terms	GO:0005829 - cytosol GO:0035556 - intracellular signal transduction GO:0035591 - signaling adaptor activity
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 303 Hs			1 456
+	Hs
		129238 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Hs
		655266 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Mm
		643068 CRKL_MOUSE (1-303): 2.79e-72: 227: 96.70		P85A_MOUSE (121-453): 4.26e-43: 163: 14.41
+	Mm
		292689 GRAP2_MOUSE (4-291): 5.63e-37: 136: 15.25		BLNK_MOUSE (1-456): 8.2e-75: 243: 85.56
+	Hs
		275217 GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97		BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00
+	Hs
		581031 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		BLNK_HUMAN (1-456): 2.24e-74: 242: 100.00
+	Mm
		1208607 PLCG2_MOUSE (5-192): 3.94e-27: 113: 18.72		BLNK_MOUSE (1-456): 8.2e-75: 243: 85.56
+	Hs
		129237 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		P85B_HUMAN (129-453): 1.23e-44: 168: 17.05
+	Mm
		140063 CRK_MOUSE (3-302): 5.71e-54: 180: 55.21		P85B_MOUSE (131-453): 3.36e-43: 163: 16.27
+	Mm
		643099 CRK_MOUSE (3-302): 5.71e-54: 180: 55.21		P85A_MOUSE (121-453): 4.26e-43: 163: 14.41
+	Hs
		655265 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		802854 CRKL_HUMAN (1-303): 6.11e-73: 228: 100.00		TENS2_HUMAN (45-436): 3.69e-23: 105: 18.06
+	Hs
		802645 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		CLNK_HUMAN (73-443): 8.86e-38: 144: 21.35
+	Hs
		802683 CRK_HUMAN (3-302): 8.95e-54: 179: 55.21		P55G_HUMAN (327-453): 3.31e-27: 115: 24.41
+	Hs
		580936 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		P85A_HUMAN (121-453): 1.18e-43: 164: 15.54
+	Hs
		275193 GRAP2_HUMAN (4-291): 5.79e-36: 133: 14.97		LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27
+	Mm
		292686 GRAP2_MOUSE (4-291): 5.63e-37: 136: 15.25		LCP2_MOUSE (14-442): 3.95e-31: 127: 22.48
+	Hs
		580995 PLCG1_HUMAN (5-224): 1.42e-28: 117: 17.80		LCP2_HUMAN (14-442): 1.33e-33: 134: 25.27
+	Mm
		1141377 PLCG1_MOUSE (5-224): 3.19e-29: 119: 16.95		LCP2_MOUSE (14-442): 3.95e-31: 127: 22.48
+	Hs
		855816 VAV2_HUMAN (14-180): 4.46e-40: 150: 19.80		TITIN_HUMAN (33-310): 7.65e-11: 67: 13.83